RPS6KA5

Ribosomal protein S6 kinase alpha-5 is an enzyme that in humans is encoded by the RPS6KA5 gene.^[5][6][7] This kinase, together with RPS6KA4, are thought to mediate the phosphorylation of histone H3, linked to the expression of immediate early genes.^[8][9]

RPS6KA5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1VZO, 3KN5, 3KN6
Identifiers
Aliases	RPS6KA5, MSK1, MSPK1, RLPK, ribosomal protein S6 kinase A5
External IDs	OMIM: 603607; MGI: 1920336; HomoloGene: 48302; GeneCards: RPS6KA5; OMA:RPS6KA5 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.11 Start 90,847,861 bp[1] End 91,060,641 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 100,514,698 bp[2] End 100,693,242 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tail of epididymis nipple corpus callosum inferior ganglion of vagus nerve buccal mucosa cell Brodmann area 23 Pons bronchial epithelial cell Skeletal muscle tissue of biceps brachii Top expressed in dorsal striatum zygote olfactory tubercle secondary oocyte lobe of cerebellum cerebellar vermis nucleus accumbens gastrula subiculum primary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding metal ion binding kinase activity protein binding ATP binding magnesium ion binding protein serine/threonine kinase activity Cellular component cytoplasm nucleoplasm nucleus Biological process intracellular signal transduction regulation of transcription, DNA-templated epidermal growth factor receptor signaling pathway phosphorylation stimulatory C-type lectin receptor signaling pathway axon guidance positive regulation of histone acetylation interleukin-1-mediated signaling pathway protein phosphorylation positive regulation of CREB transcription factor activity positive regulation of NF-kappaB transcription factor activity inflammatory response negative regulation of transcription, DNA-templated negative regulation of cytokine production positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9252 73086 Ensembl ENSG00000100784 ENSMUSG00000021180 UniProt O75582 Q8C050 RefSeq (mRNA) NM_004755 NM_182398 NM_001322227 NM_001322228 NM_001322229 NM_001322230 NM_001322231 NM_001322232 NM_001322233 NM_001322234 NM_001322235 NM_001322236 NM_001322237 NM_001322238 NM_153587 NM_001330702 RefSeq (protein) NP_001309156 NP_001309157 NP_001309158 NP_001309159 NP_001309160 NP_001309161 NP_001309162 NP_001309163 NP_001309164 NP_001309165 NP_001309166 NP_001309167 NP_004746 NP_872198 NP_001317631 NP_705815 Location (UCSC) Chr 14: 90.85 – 91.06 Mb Chr 12: 100.51 – 100.69 Mb PubMed search [3] [4]
Wikidata
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Interactions

RPS6KA5 has been shown to interact with CREB1.^[5][10]