RPS6KA1

"HU-1" redirects here. For the helicopter, see UH-1 Iroquois.

Ribosomal protein S6 kinase alpha-1 is an enzyme that in humans is encoded by the RPS6KA1 gene.^[5]

RPS6KA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WNT, 2Z7Q, 2Z7R, 2Z7S, 3RNY, 4H3P, 4NIF, 5CSJ, 5CSF, 5CSN, 5CSI
Identifiers
Aliases	RPS6KA1, HU-1, MAPKAPK1A, RSK, RSK1, p90Rsk, ribosomal protein S6 kinase A1, MAPKAPK1
External IDs	OMIM: 601684; MGI: 104558; HomoloGene: 55703; GeneCards: RPS6KA1; OMA:RPS6KA1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 26,529,761 bp[1] End 26,575,030 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D2.3 Start 133,574,601 bp[2] End 133,615,108 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood granulocyte mucosa of transverse colon monocyte duodenum spleen lymph node appendix rectum bone marrow Top expressed in granulocyte crypt of lieberkuhn of small intestine duodenum left colon jejunum ileum vestibular membrane of cochlear duct tibiofemoral joint gastric mucosa epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity metal ion binding cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein serine/threonine kinase activity protein binding protein serine/threonine/tyrosine kinase activity ATP binding magnesium ion binding kinase activity ribosomal protein S6 kinase activity Cellular component nucleoplasm nucleus cytoplasm cytosol Biological process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of translation in response to stress intracellular signal transduction phosphorylation negative regulation of apoptotic process protein phosphorylation positive regulation of cell growth hepatocyte proliferation positive regulation of cell differentiation positive regulation of hepatic stellate cell activation cell cycle regulation of DNA-templated transcription in response to stress signal transduction positive regulation of transcription by RNA polymerase II apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6195 20111 Ensembl ENSG00000117676 ENSG00000281877 ENSMUSG00000003644 UniProt Q15418 P18653 RefSeq (mRNA) NM_001006665 NM_002953 NM_001330441 NM_001285505 NM_001285506 NM_009097 NM_001378880 RefSeq (protein) NP_001006666 NP_001317370 NP_002944 NP_001272434.1 Location (UCSC) Chr 1: 26.53 – 26.58 Mb Chr 4: 133.57 – 133.62 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]

Interactions

RPS6KA1 has been shown to interact with:

• IκBα,^[7]
• MAPK1,^[8][9][10]
• TOB1^[11]
• TSC2,^[12][13] and
• YWHAB.^[14]

See also

• Ribosomal s6 kinase