ROBO3

Roundabout homolog 3 is a protein that in humans is encoded by the ROBO3 gene.^[5][6]

ROBO3
Identifiers
Aliases	ROBO3, HGPPS, HGPS, RBIG1, RIG1, roundabout guidance receptor 3, HGPPS1
External IDs	OMIM: 608630; MGI: 1343102; HomoloGene: 32119; GeneCards: ROBO3; OMA:ROBO3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.2 Start 124,865,432 bp[1] End 124,881,471 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A4 Start 37,326,965 bp[2] End 37,344,542 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube left ovary right ovary vena cava sural nerve left uterine tube Amygdala right frontal lobe tendon of biceps brachii C1 segment Top expressed in gray matter layer of cerebellum superior frontal gyrus primary visual cortex nerve fascicle rhombic lip habenula outer nuclear layer embryo inner nuclear layer secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cell-cell adhesion mediator activity Cellular component integral component of membrane axon membrane plasma membrane Biological process multicellular organism development chemotaxis cell differentiation axon midline choice point recognition Roundabout signaling pathway nervous system development axon guidance homophilic cell adhesion via plasma membrane adhesion molecules chemoattraction of axon dendrite self-avoidance commissural neuron axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64221 19649 Ensembl ENSG00000154134 ENSMUSG00000032128 UniProt Q96MS0 Q9Z2I4 RefSeq (mRNA) NM_022370 NM_001164767 NM_011248 RefSeq (protein) NP_071765 NP_001357285 NP_001357286 NP_001357287 NP_001357288 NP_001357290 NP_001357293 NP_001357295 n/a Location (UCSC) Chr 11: 124.87 – 124.88 Mb Chr 9: 37.33 – 37.34 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000154134 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000032128 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jen JC, Chan WM, Bosley TM, Wan J, Carr JR, Rub U, Shattuck D, Salamon G, Kudo LC, Ou J, Lin DD, Salih MA, Kansu T, Al Dhalaan H, Al Zayed Z, MacDonald DB, Stigsby B, Plaitakis A, Dretakis EK, Gottlob I, Pieh C, Traboulsi EI, Wang Q, Wang L, Andrews C, Yamada K, Demer JL, Karim S, Alger JR, Geschwind DH, Deller T, Sicotte NL, Nelson SF, Baloh RW, Engle EC (Jun 2004). "Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis". Science. 304 (5676): 1509–13. Bibcode:2004Sci...304.1509J. doi:10.1126/science.1096437. PMC 1618874. PMID 15105459.
6. "Entrez Gene: ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Yuan SS, Cox LA, Dasika GK, Lee EY (1999). "Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos". Dev. Biol. 207 (1): 62–75. doi:10.1006/dbio.1998.9141. PMID 10049565.
• Jen J, Coulin CJ, Bosley TM, et al. (2002). "Familial horizontal gaze palsy with progressive scoliosis maps to chromosome 11q23-25". Neurology. 59 (3): 432–5. doi:10.1212/wnl.59.3.432. PMID 12177379. S2CID 32947142.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Bosley TM, Salih MA, Jen JC, et al. (2006). "Neurologic features of horizontal gaze palsy and progressive scoliosis with mutations in ROBO3". Neurology. 64 (7): 1196–203. doi:10.1212/01.WNL.0000156349.01765.2B. PMID 15824346. S2CID 72500917.
• Camurri L, Mambetisaeva E, Davies D, et al. (2006). "Evidence for the existence of two Robo3 isoforms with divergent biochemical properties". Mol. Cell. Neurosci. 30 (4): 485–93. doi:10.1016/j.mcn.2005.07.014. PMID 16226035. S2CID 41242127.
• Chan WM, Traboulsi EI, Arthur B, et al. (2006). "Horizontal gaze palsy with progressive scoliosis can result from compound heterozygous mutations in ROBO3". J. Med. Genet. 43 (3): e11. doi:10.1136/jmg.2005.035436. PMC 2563249. PMID 16525029.