RIPK4

Receptor-interacting serine/threonine-protein kinase 4 is an enzyme that in humans is encoded by the RIPK4 gene.^[5][6]

RIPK4
Identifiers
Aliases	RIPK4, ANKK2, ANKRD3, DIK, NKRD3, PKK, PPS2, RIP4, receptor interacting serine/threonine kinase 4, CHANDS
External IDs	OMIM: 605706; MGI: 1919638; HomoloGene: 10772; GeneCards: RIPK4; OMA:RIPK4 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 41,739,369 bp[1] End 41,767,089 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 C4 Start 97,543,133 bp[2] End 97,564,987 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium palpebral conjunctiva oral cavity amniotic fluid epithelium of bronchus mucosa of paranasal sinus nasal epithelium bronchial epithelial cell mucosa of pharynx kidney tubule Top expressed in transitional epithelium of urinary bladder conjunctival fornix hair follicle seminal vesicula skin of external ear skin of abdomen skin of back epithelium of small intestine cornea vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine kinase activity ATP binding kinase activity nucleotide binding protein kinase activity transferase activity protein binding Cellular component membrane cytoplasm Biological process protein phosphorylation morphogenesis of an epithelium positive regulation of NF-kappaB transcription factor activity phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54101 72388 Ensembl ENSG00000183421 ENSMUSG00000005251 UniProt P57078 Q9ERK0 RefSeq (mRNA) NM_020639 NM_023663 RefSeq (protein) n/a NP_076152 Location (UCSC) Chr 21: 41.74 – 41.77 Mb Chr 16: 97.54 – 97.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation.^[6]

Interactions

RIPK4 has been shown to interact with PRKCB1.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000183421 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005251 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hattori M, Fujiyama A, Taylor TD, Watanabe H, Yada T, Park HS, Toyoda A, Ishii K, Totoki Y, Choi DK, Groner Y, Soeda E, Ohki M, Takagi T, Sakaki Y, Taudien S, Blechschmidt K, Polley A, Menzel U, Delabar J, Kumpf K, Lehmann R, Patterson D, Reichwald K, Rump A, Schillhabel M, Schudy A, Zimmermann W, Rosenthal A, Kudoh J, Schibuya K, Kawasaki K, Asakawa S, Shintani A, Sasaki T, Nagamine K, Mitsuyama S, Antonarakis SE, Minoshima S, Shimizu N, Nordsiek G, Hornischer K, Brant P, Scharfe M, Schon O, Desario A, Reichelt J, Kauer G, Blocker H, Ramser J, Beck A, Klages S, Hennig S, Riesselmann L, Dagand E, Haaf T, Wehrmeyer S, Borzym K, Gardiner K, Nizetic D, Francis F, Lehrach H, Reinhardt R, Yaspo ML (June 2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
6. "Entrez Gene: RIPK4 receptor-interacting serine-threonine kinase 4".
7. Chen, L; Haider K; Ponda M; Cariappa A; Rowitch D; Pillai S (June 2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. ISSN 0021-9258. PMID 11278382.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Bhr C, Rohwer A, Stempka L, et al. (2000). "DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis". J. Biol. Chem. 275 (46): 36350–7. doi:10.1074/jbc.M004771200. PMID 10948194.
• Chen L, Haider K, Ponda M, et al. (2001). "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". J. Biol. Chem. 276 (24): 21737–44. doi:10.1074/jbc.M008069200. PMID 11278382.
• Meylan E, Martinon F, Thome M, et al. (2003). "RIP4 (DIK/PKK), a novel member of the RIP kinase family, activates NF-κB and is processed during apoptosis". EMBO Rep. 3 (12): 1201–8. doi:10.1093/embo-reports/kvf236. PMC 1308326. PMID 12446564.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Moran ST, Haider K, Ow Y, et al. (2003). "Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner". J. Biol. Chem. 278 (24): 21526–33. doi:10.1074/jbc.M301575200. PMID 12676934.
• Scanlan MJ, Gout I, Gordon CM, et al. (2003). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immun. 1: 4. PMID 12747765.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Adams S, Pankow S, Werner S, Munz B (2007). "Regulation of NF-kappaB activity and keratinocyte differentiation by the RIP4 protein: implications for cutaneous wound repair". J. Invest. Dermatol. 127 (3): 538–44. doi:10.1038/sj.jid.5700588. PMID 17039240.

External links

• RIPK4 human gene location in the UCSC Genome Browser.
• RIPK4 human gene details in the UCSC Genome Browser.