RFX3

Transcription factor RFX3 is a protein that in humans is encoded by the RFX3 gene.^[5][6]

RFX3
Identifiers
Aliases	RFX3, regulatory factor X3
External IDs	OMIM: 601337; MGI: 106582; HomoloGene: 7917; GeneCards: RFX3; OMA:RFX3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p24.2 Start 3,218,297 bp[1] End 3,526,004 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 27,739,121 bp[2] End 27,988,566 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bronchial epithelial cell mucosa of paranasal sinus Brodmann area 23 middle temporal gyrus cerebellar vermis right uterine tube caput epididymis ventricular zone corpus callosum entorhinal cortex Top expressed in olfactory epithelium Epithelium of choroid plexus piriform cortex medial ganglionic eminence anterior amygdaloid area dentate gyrus tail of embryo Region I of hippocampus proper primitive streak olfactory tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding sequence-specific DNA binding DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus extracellular region Biological process cell differentiation regulation of transcription, DNA-templated positive regulation of type B pancreatic cell development regulation of insulin secretion epithelial cilium movement involved in determination of left/right asymmetry cell maturation transcription, DNA-templated positive regulation of transcription, DNA-templated multicellular organism development type B pancreatic cell maturation determination of left/right symmetry negative regulation of transcription, DNA-templated cilium-dependent cell motility endocrine pancreas development positive regulation of transcription by RNA polymerase II type B pancreatic cell differentiation cilium assembly regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5991 19726 Ensembl ENSG00000080298 ENSMUSG00000040929 UniProt P48380 P48381 RefSeq (mRNA) NM_001282116 NM_001282117 NM_002919 NM_134428 NM_001377999 NM_001166414 NM_011265 NM_001360357 NM_001360358 RefSeq (protein) NP_001269045 NP_001269046 NP_002910 NP_602304 NP_001364928 NP_001159886 NP_035395 NP_001347286 NP_001347287 Location (UCSC) Chr 9: 3.22 – 3.53 Mb Chr 19: 27.74 – 27.99 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. Two transcript variants encoding different isoforms have been described for this gene, and at least one of the variants utilizes alternative polyadenylation signals.^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000080298 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040929 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Reith W, Ucla C, Barras E, Gaud A, Durand B, Herrero-Sanchez C, Kobr M, Mach B (Feb 1994). "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins". Mol Cell Biol. 14 (2): 1230–44. doi:10.1128/mcb.14.2.1230. PMC 358479. PMID 8289803.
6. "Entrez Gene: RFX3 regulatory factor X, 3 (influences HLA class II expression)".

Further reading

• Emery P, Durand B, Mach B, Reith W (1996). "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom". Nucleic Acids Res. 24 (5): 803–7. doi:10.1093/nar/24.5.803. PMC 145730. PMID 8600444.
• Iwama A, Pan J, Zhang P, et al. (1999). "Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains". Mol. Cell. Biol. 19 (6): 3940–50. doi:10.1128/mcb.19.6.3940. PMC 104353. PMID 10330134.
• Morotomi-Yano K, Yano K, Saito H, et al. (2002). "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members". J. Biol. Chem. 277 (1): 836–42. doi:10.1074/jbc.M108638200. PMID 11682486.
• Nakayama A, Murakami H, Maeyama N, et al. (2003). "Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter". J. Biol. Chem. 278 (1): 233–40. doi:10.1074/jbc.M209574200. PMID 12411430.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element". Arch. Dermatol. Res. 295 (11): 482–9. doi:10.1007/s00403-004-0456-5. PMID 15024578. S2CID 2408607.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.