RANBP9

Ran-binding protein 9 is a protein that in humans is encoded by the RANBP9 gene.^[5][6]

RANBP9
Identifiers
Aliases	RANBP9, Ranbp9, IBAP-1, Ibap1, RanBPM, BPM-L, BPM90, RanBP7, RAN binding protein 9
External IDs	OMIM: 603854; MGI: 1928741; HomoloGene: 38057; GeneCards: RANBP9; OMA:RANBP9 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p23 Start 13,621,498 bp[1] End 13,711,835 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A4 Start 43,556,151 bp[2] End 43,634,758 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte Brodmann area 23 endothelial cell amniotic fluid oral cavity mucosa of pharynx skin of thigh human penis gingival epithelium Top expressed in zygote secondary oocyte spermatid spermatocyte ascending aorta seminiferous tubule aortic valve granulocyte tail of embryo genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function enzyme binding protein binding Cellular component cytoplasm cytosol plasma membrane membrane nucleus microtubule associated complex ubiquitin ligase complex Biological process negative regulation of ERK1 and ERK2 cascade microtubule nucleation axon guidance MAPK cascade protein-containing complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10048 56705 Ensembl ENSG00000010017 ENSMUSG00000038546 UniProt Q96S59 P69566 RefSeq (mRNA) NM_005493 NM_019930 RefSeq (protein) NP_005484 NP_064314 NP_001391577 Location (UCSC) Chr 6: 13.62 – 13.71 Mb Chr 13: 43.56 – 43.63 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes a protein that binds RAN, a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The protein encoded by this gene has also been shown to interact with several other proteins, including met proto-oncogene, homeodomain interacting protein kinase 2, androgen receptor, and cyclin-dependent kinase 11.^[6]

Interactions

RANBP9 has been shown to interact with:

• Androgen receptor,^[7]
• C-Met,^[8]
• DISC1,^[9]
• DYRK1B,^[10]
• Glucocorticoid receptor,^[7]
• HIPK2^[11]
• MKLN1,^[12]
• S100A7,^[13] and
• USP11.^[14]

References

1. GRCh38: Ensembl release 89: ENSG00000010017 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038546 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nakamura M, Masuda H, Horii J, Kuma Ki, Yokoyama N, Ohba T, Nishitani H, Miyata T, Tanaka M, Nishimoto T (Dec 1998). "When Overexpressed, a Novel Centrosomal Protein, RanBPM, Causes Ectopic Microtubule Nucleation Similar to γ-Tubulin". J Cell Biol. 143 (4): 1041–52. doi:10.1083/jcb.143.4.1041. PMC 2132962. PMID 9817760.
6. "Entrez Gene: RANBP9 RAN binding protein 9".
7. Rao MA, Cheng H, Quayle AN, Nishitani H, Nelson CC, Rennie PS (Dec 2002). "RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor". J. Biol. Chem. 277 (50): 48020–7. doi:10.1074/jbc.M209741200. PMID 12361945.
8. Wang D, Li Z, Messing EM, Wu G (Sep 2002). "Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM". J. Biol. Chem. 277 (39): 36216–22. doi:10.1074/jbc.M205111200. PMID 12147692.
9. Morris JA, Kandpal G, Ma L, Austin CP (Jul 2003). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
10. Zou Y, Lim S, Lee K, Deng X, Friedman E (Dec 2003). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M". J. Biol. Chem. 278 (49): 49573–81. doi:10.1074/jbc.M307556200. PMID 14500717.
11. Wang Y, Marion Schneider E, Li X, Duttenhöfer I, Debatin K, Hug H (Sep 2002). "HIPK2 associates with RanBPM". Biochem. Biophys. Res. Commun. 297 (1): 148–53. doi:10.1016/S0006-291X(02)02020-X. PMID 12220523.
12. Umeda M, Nishitani H, Nishimoto T (Jan 2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". Gene. 303: 47–54. doi:10.1016/s0378-1119(02)01153-8. PMID 12559565.
13. Emberley ED, Gietz RD, Campbell JD, HayGlass KT, Murphy LC, Watson PH (Nov 2002). "RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer". BMC Cancer. 2: 28. doi:10.1186/1471-2407-2-28. PMC 137593. PMID 12421467.
14. Ideguchi H, Ueda A, Tanaka M, Yang J, Tsuji T, Ohno S, Hagiwara E, Aoki A, Ishigatsubo Y (Oct 2002). "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM". Biochem. J. 367 (Pt 1): 87–95. doi:10.1042/BJ20011851. PMC 1222860. PMID 12084015.

Further reading

• Nishimoto T (1999). "A new role of ran GTPase". Biochem. Biophys. Res. Commun. 262 (3): 571–4. doi:10.1006/bbrc.1999.1252. PMID 10471364.
• Kozak M (2003). "Emerging links between initiation of translation and human diseases". Mamm. Genome. 13 (8): 401–10. doi:10.1007/s00335-002-4002-5. PMID 12226704. S2CID 25690586.
• Nishitani H, Hirose E, Uchimura Y, Nakamura M, Umeda M, Nishii K, Mori N, Nishimoto T (2001). "Full-sized RanBPM cDNA encodes a protein possessing a long stretch of proline and glutamine within the N-terminal region, comprising a large protein complex". Gene. 272 (1–2): 25–33. doi:10.1016/S0378-1119(01)00553-4. PMID 11470507.
• Caballero OL, Resto V, Patturajan M, Meerzaman D, Guo MZ, Engles J, Yochem R, Ratovitski E, Sidransky D, Jen J (2002). "Interaction and colocalization of PGP9.5 with JAB1 and p27(Kip1)". Oncogene. 21 (19): 3003–10. doi:10.1038/sj.onc.1205390. PMID 12082530. S2CID 20004395.
• Ideguchi H, Ueda A, Tanaka M, Yang J, Tsuji T, Ohno S, Hagiwara E, Aoki A, Ishigatsubo Y (2003). "Structural and functional characterization of the USP11 deubiquitinating enzyme, which interacts with the RanGTP-associated protein RanBPM". Biochem. J. 367 (Pt 1): 87–95. doi:10.1042/BJ20011851. PMC 1222860. PMID 12084015.
• Wang D, Li Z, Messing EM, Wu G (2002). "Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM". J. Biol. Chem. 277 (39): 36216–22. doi:10.1074/jbc.M205111200. PMID 12147692.
• Wang Y, Marion Schneider E, Li X, Duttenhöfer I, Debatin K, Hug H (2002). "HIPK2 associates with RanBPM". Biochem. Biophys. Res. Commun. 297 (1): 148–53. doi:10.1016/S0006-291X(02)02020-X. PMID 12220523.
• Rao MA, Cheng H, Quayle AN, Nishitani H, Nelson CC, Rennie PS (2003). "RanBPM, a nuclear protein that interacts with and regulates transcriptional activity of androgen receptor and glucocorticoid receptor". J. Biol. Chem. 277 (50): 48020–7. doi:10.1074/jbc.M209741200. PMID 12361945.
• Emberley ED, Gietz RD, Campbell JD, HayGlass KT, Murphy LC, Watson PH (2003). "RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer". BMC Cancer. 2: 28. doi:10.1186/1471-2407-2-28. PMC 137593. PMID 12421467.
• Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). "Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin". Biochem. Biophys. Res. Commun. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. PMID 12470648.
• Umeda M, Nishitani H, Nishimoto T (2003). "A novel nuclear protein, Twa1, and Muskelin comprise a complex with RanBPM". Gene. 303: 47–54. doi:10.1016/S0378-1119(02)01153-8. PMID 12559565.
• Lutz W, Frank EM, Craig TA, Thompson R, Venters RA, Kojetin D, Cavanagh J, Kumar R (2003). "Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy". Biochem. Biophys. Res. Commun. 303 (4): 1186–92. doi:10.1016/S0006-291X(03)00499-6. PMID 12684061.
• Yao X, Wang HL, Shi ZX, Yan XY, Feng EL, Yang BL, Huang LY (2003). "Identification of RanBMP interacting with Shigella flexneri IpaC invasin by two-hybrid system of yeast". World J. Gastroenterol. 9 (6): 1347–51. doi:10.3748/wjg.v9.i6.1347. PMC 4611814. PMID 12800254.
• Morris JA, Kandpal G, Ma L, Austin CP (2004). "DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation". Hum. Mol. Genet. 12 (13): 1591–608. doi:10.1093/hmg/ddg162. PMID 12812986.
• Zou Y, Lim S, Lee K, Deng X, Friedman E (2004). "Serine/threonine kinase Mirk/Dyrk1B is an inhibitor of epithelial cell migration and is negatively regulated by the Met adaptor Ran-binding protein M". J. Biol. Chem. 278 (49): 49573–81. doi:10.1074/jbc.M307556200. PMID 14500717.
• Mikolajczyk M, Shi J, Vaillancourt RR, Sachs NA, Nelson M (2003). "The cyclin-dependent kinase 11(p46) isoform interacts with RanBPM". Biochem. Biophys. Res. Commun. 310 (1): 14–8. doi:10.1016/j.bbrc.2003.08.116. PMID 14511641.

External links

• RANBP9 human gene location in the UCSC Genome Browser.
• RANBP9 human gene details in the UCSC Genome Browser.