RAB6C

Ras-related protein Rab-6C is a protein that in humans is encoded by the RAB6C gene.^[3][4][5]

RAB6C
Identifiers
Aliases	RAB6C, WTH3, member RAS oncogene family
External IDs	OMIM: 612909; HomoloGene: 108091; GeneCards: RAB6C; OMA:RAB6C - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q21.1 Start 129,979,666 bp[1] End 129,982,738 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle endometrium primary visual cortex superior frontal gyrus prefrontal cortex hippocampus proper Brodmann area 9 corpus callosum putamen gonad n/a More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding GTPase activity Cellular component cytoplasm centrosome intracellular anatomical structure cytoskeleton nucleus microtubule organizing center cytosol Golgi apparatus Biological process regulation of centrosome duplication retrograde transport, endosome to Golgi intra-Golgi vesicle-mediated transport retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum mitotic cell cycle small GTPase mediated signal transduction intracellular protein transport Rab protein signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84084 n/a Ensembl ENSG00000222014 n/a UniProt Q9H0N0 n/a RefSeq (mRNA) NM_032144 n/a RefSeq (protein) NP_115520 n/a Location (UCSC) Chr 2: 129.98 – 129.98 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

References

1. GRCh38: Ensembl release 89: ENSG00000222014 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Shan J, Mason JM, Yuan L, Barcia M, Porti D, Calabro A, Budman D, Vinciguerra V, Xu H (Dec 2000). "Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells". Gene. 257 (1): 67–75. doi:10.1016/S0378-1119(00)00395-4. PMID 11054569.
4. Tian K, Wang Y, Xu H (May 2007). "WTH3 is a direct target of the p53 protein". Br J Cancer. 96 (10): 1579–86. doi:10.1038/sj.bjc.6603724. PMC 2359938. PMID 17426708.
5. "Entrez Gene: RAB6C RAB6C, member RAS oncogene family".

Further reading

• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Fitzgerald ML; Reed GL (1999). "Rab6 is phosphorylated in thrombin-activated platelets by a protein kinase C-dependent mechanism: effects on GTP/GDP binding and cellular distribution". Biochem. J. 342 ( Pt 2) (2): 353–60. doi:10.1042/0264-6021:3420353. PMC 1220472. PMID 10455022.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Shan J; Yuan L; Budman DR; Xu HP (2002). "WTH3, a new member of the Rab6 gene family, and multidrug resistance". Biochim. Biophys. Acta. 1589 (2): 112–23. doi:10.1016/S0167-4889(02)00164-7. PMID 12007787.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Tian K, Jurukovski V, Wang XP, et al. (2005). "Epigenetic regulation of WTH3 in primary and cultured drug-resistant breast cancer cells". Cancer Res. 65 (21): 10024–31. doi:10.1158/0008-5472.CAN-05-1944. PMID 16267028.