Pynazolam

Pynazolam is a triazolobenzodiazepine derivative first invented in the 1970s,^[1] which has in more recent years been sold online as a designer drug. Anecdotal reports and in silico studies suggest it has relatively potent hypnotic and sedative effects.^{[medical citation needed]} Pynazolam is a powerful serotonin releaser similar to nimetazepam^[2] which increases hypnotic activity and euphoria. Anecdotal evidence has also suggested that it's subjective effects are similar to methaqualone^[3] although unlike methaqualone, it cannot be smoked or vaporised due to its high melting & boiling point.

Pynazolam

Identifiers
IUPAC name 1-methyl-8-nitro-6-(pyridin-2-yl)-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine
CAS Number	2034366-97-5
PubChem CID	20368157
ChemSpider	15417687
Chemical and physical data
Formula	C16H12N6O2
Molar mass	320.312 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=NN=C2N1C3=C(C=C(C=C3)[N+](=O)[O-])C(=NC2)C4=CC=CC=N4
InChI InChI=1S/C16H12N6O2/c1-10-19-20-15-9-18-16(13-4-2-3-7-17-13)12-8-11(22(23)24)5-6-14(12)21(10)15/h2-8H,9H2,1H3 Key:TULLJLNDPPOHKC-UHFFFAOYSA-N

Limited pharmacological data is available^[4] although there is an increasing availability of the compound for research purposes.^[5]

See also

• Clonazolam
• Flunitrazolam
• Nitrazolam
• Pyeazolam
• Pyrazolam
• List of benzodiazepines

References

1. US 3970664, Sternbach LH, Walser A, "Preparation of triazolo benzodiazepines.", issued 20 July 1976, assigned to Hoffmann-LaRoche, Inc.
2. Pranzatelli, Michael R. (1989). "Benzodiazepine-induced shaking behavior in the rat: Structure-activity and relation to serotonin and benzodiazepine receptors". Experimental Neurology. 104 (3): 241–250. doi:10.1016/0014-4886(89)90036-8.
3. https://bluelight.org/xf/threads/flubromazolam-retrospective-6-years-with-the-knockout-night-nurse.892802/page-7
4. Catalani V, Floresta G, Botha M, Corkery JM, Guirguis A, Vento A, et al. (January 2023). "In silico studies on recreational drugs: 3D quantitative structure activity relationship prediction of classified and de novo designer benzodiazepines". Chemical Biology & Drug Design. 101 (1): 40–51. doi:10.1111/cbdd.14119. hdl:2299/25749. PMID 35838189.
5. https://pubchem.ncbi.nlm.nih.gov/compound/20368157