Prosolanapyrone-III cycloisomerase

Prosolanapyrone-III cycloisomerase (EC 5.5.1.20, Sol5, SPS, solanapyrone synthase (bifunctional enzyme: prosolanapyrone II oxidase/prosolanapyrone III cyclosiomerase)) is an enzyme with systematic name prosolanapyrone-III:(-)-solanapyrone A isomerase.^[1][2][3] This enzyme catalyses the following chemical reaction

prosolanapyrone III ${\displaystyle \rightleftharpoons }$ (-)-solanapyrone A

Prosolanapyrone-III cycloisomerase
Identifiers
EC no.	5.5.1.20
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone in some fungi.

References

1. Kasahara K, Miyamoto T, Fujimoto T, Oguri H, Tokiwano T, Oikawa H, Ebizuka Y, Fujii I (June 2010). "Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani". ChemBioChem. 11 (9): 1245–52. doi:10.1002/cbic.201000173. PMID 20486243.
2. Katayama K, Kobayashi T, Oikawa H, Honma M, Ichihara A (May 1998). "Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology. 1384 (2): 387–95. doi:10.1016/s0167-4838(98)00040-5. PMID 9659400.
3. Katayama K, Kobayashi T, Chijimatsu M, Ichihara A, Oikawa H (February 2008). "Purification and N-terminal amino acid sequence of solanapyrone synthase, a natural Diels-Alderase from Alternaria solani". Bioscience, Biotechnology, and Biochemistry. 72 (2): 604–7. doi:10.1271/bbb.70600. PMID 18256508.

External links

• Prosolanapyrone-III+cycloisomerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)