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Chemical compound From Wikipedia, the free encyclopedia
Promestriene (INN ) (brand names Colpotrofin, Colpotrophine, Delipoderm), also known as estradiol 3-propyl 17β-methyl diether, is a synthetic estrogen which is used topically in a 1% cream formulation for the treatment of vaginal atrophy in women.[1][2][3][4][5] It is the 3-propyl and 17β-methyl diether of estradiol and does not appear to convert into estradiol in the body.[1][6] Promestriene is minimally absorbed and appears to have negligible systemic estrogenic effect.[1] The drug has been described as a tropic agent and antiseborrheic.[2] It has not been found to be effective in the treatment of pattern hair loss or other conditions of cutaneous androgenization.[7][8] Promestriene was first introduced in France in 1974 and has been marketed in 34 countries worldwide.[1] It has been used in millions of women.[1]
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Trade names | Colpotrofin, Colpotrophine, Delipoderm |
Other names | Estradiol 3-propyl 17β-methyl diether; 17β-Methoxy-3-propoxyestra-1,3,5(10)-triene |
Routes of administration | Topical |
Drug class | Estrogen; Estrogen ester |
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ECHA InfoCard | 100.049.401 |
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Formula | C22H32O2 |
Molar mass | 328.496 g·mol−1 |
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