Prokineticin receptor

The prokineticin receptor is a G protein-coupled receptor which binds the peptide hormone prokineticin. There are two variants each encoded by a different gene (PROKR1, PROKR2).^[1] These receptors mediate gastrointestinal smooth muscle contraction and angiogenesis.

prokineticin receptor 1
Identifiers
Symbol	PROKR1
Alt. symbols	GPR73
NCBI gene	10887
HGNC	4524
OMIM	607122
RefSeq	NM_138964
UniProt	Q8TCW9
Other data
Locus	Chr. 2 p14
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prokineticin receptor 2
Identifiers
Symbol	PROKR2
Alt. symbols	GPR73L1
NCBI gene	128674
HGNC	15836
OMIM	607123
RefSeq	NM_144773
UniProt	Q8NFJ6
Other data
Locus	Chr. 20 p12.3
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References

1. Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY (2002). "Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor". J. Biol. Chem. 277 (22): 19276–80. doi:10.1074/jbc.M202139200. PMID 11886876.

External links

• "Prokineticin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2011-05-16. Retrieved 2007-10-25.
• PROKR1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• PROKR2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)