Plakophilin

Plakophilin are proteins of the cytoskeleton.^[1] They are involved in regulating the adhesive activity of cadherin.^[2]

The three types of plakophilin proteins found in humans are PKP1, PKP2, and PKP3; all exhibiting dual localization in the nucleus as well as desmosomes.^[3][4]

Genes include:

• PKP1
• PKP2
• PKP3

See also

• List of conditions caused by problems with junctional proteins

References

1. Plakophilins at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
2. Kline CF, Mohler PJ (2013-01-01). Bennett V (ed.). "Evolving form to fit function: cardiomyocyte intercalated disc and transverse-tubule membranes". Current Topics in Membranes. Functional Organization of Vertebrate Plasma Membrane. 72. Academic Press: 121–58. doi:10.1016/b978-0-12-417027-8.00004-0. PMID 24210429. Retrieved 2020-10-22.
3. Schwab M, ed. (2011). Encyclopedia of Cancer (2011 ed.). Springer, Berlin, Heidelberg. p. 252. doi:10.1007/978-3-642-16483-5. ISBN 978-3-642-16483-5. S2CID 27502611.
4. Miller RK, Hong JY, Muñoz WA, McCrea PD (January 2013). van Roy F (ed.). "Beta-catenin versus the other armadillo catenins: assessing our current view of canonical Wnt signaling". Progress in Molecular Biology and Translational Science. The Molecular Biology of Cadherins. 116. Academic Press: 387–407. doi:10.1016/b978-0-12-394311-8.00017-0. PMC 3752792. PMID 23481204.