Pipofezine

Pipofezine, sold under the brand name Azafen or Azaphen, is a tricyclic antidepressant approved in Russia for the treatment of depression.^[1][2][3][4] It was introduced in the late 1960s and is still used today.^[5][6]

Pipofezine

Clinical data
Trade names	Azafen, Azaphen
Routes of administration	Oral
ATC code	none
Legal status
Legal status	In general: ℞ (Prescription only)
Identifiers
IUPAC name 5-methyl-3-(4-methylpiperazin-1-yl)pyridazino[3,4-b][1,4]benzoxazine
CAS Number	24886-52-0
PubChem CID	159977
ChemSpider	140640
UNII	P8T739L1FA
CompTox Dashboard (EPA)	DTXSID5046271
Chemical and physical data
Formula	C16H19N5O
Molar mass	297.362 g·mol−1

Pipofezine has been shown to act as a potent inhibitor of the reuptake of serotonin.^[7][8] In addition to its antidepressant action, pipofezine has sedative effects as well, suggesting antihistamine activity.^[9] Other properties such as anticholinergic or antiadrenergic actions are less clear but are likely.^{[citation needed]}

See also

• Fluacizine
• List of Russian drugs