Picornavirus internal ribosome entry site (IRES)

This family represents the Picornavirus internal ribosome entry site (IRES) element present in their 5' untranslated region.^[1] These elements were discovered in picornaviruses.^[2] They are cis-acting RNA sequences that adopt diverse three-dimensional structures, recruit the translation machinery and that often operate in association with specific RNA-binding proteins.^[2] IRES elements allow cap and end-independent translation of mRNA in the host cell. It has been found that La autoantigen (La) is required for Coxsackievirus B3 (CVB3) IRES-mediated translation, and it has been suggested that La may be required for the efficient translation of the viral RNA in the pancreas.^[3][4] Based on their secondary structure, picornavirus IRES are grouped into four main types. Type I comprises enteroand rhinovirus IRES and type II, those of cardio- and aphthovirus, among others. Type III is used to name hepatitis A IRES.^[2]

Picornavirus internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Picorna
Identifiers
Symbol	IRES_Picorna
Rfam	RF00229
Other data
RNA type	Cis-reg; IRES
Domain(s)	Viruses
GO	GO:0043022
SO	SO:0000243
PDB structures	PDBe