Phytoene desaturase (3,4-didehydrolycopene-forming)

Phytoene desaturase (3,4-didehydrolycopene-forming) (EC 1.3.99.30, 5-step phytoene desaturase, five-step phytoene desaturase, phytoene desaturase (ambiguous), Al-1) is an enzyme with systematic name 15-cis-phytoene:acceptor oxidoreductase (3,4-didehydrolycopene-forming).^[1][2] This enzyme catalyses the following chemical reaction

15-cis-phytoene + 5 acceptor ${\displaystyle \rightleftharpoons }$ all-trans-3,4-didehydrolycopene + 5 reduced acceptor (overall reaction)

(1a) 15-cis-phytoene + acceptor ${\displaystyle \rightleftharpoons }$ all-trans-phytofluene + reduced acceptor

(1b) all-trans-phytofluene + acceptor ${\displaystyle \rightleftharpoons }$ all-trans-zeta-carotene + reduced acceptor

(1c) all-trans-zeta-carotene + acceptor ${\displaystyle \rightleftharpoons }$ all-trans-neurosporene + reduced acceptor

(1d) all-trans-neurosporene + acceptor ${\displaystyle \rightleftharpoons }$ all-trans-lycopene + reduced acceptor

(1e) all-trans-lycopene + acceptor ${\displaystyle \rightleftharpoons }$ all-trans-3,4-didehydrolycopene + reduced acceptor

Phytoene desaturase (3,4-didehydrolycopene-forming)
Identifiers
EC no.	1.3.99.30
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

This enzyme is involved in carotenoid biosynthesis.

See also

• Phytoene desaturase (lycopene-forming)
• Phytoene desaturase (neurosporene-forming)
• Phytoene desaturase (zeta-carotene-forming)
• 15-Cis-phytoene desaturase

References

1. Hausmann A, Sandmann G (July 2000). "A single five-step desaturase is involved in the carotenoid biosynthesis pathway to beta-carotene and torulene in Neurospora crassa". Fungal Genetics and Biology. 30 (2): 147–53. doi:10.1006/fgbi.2000.1212. PMID 11017770.
2. Estrada AF, Maier D, Scherzinger D, Avalos J, Al-Babili S (November 2008). "Novel apocarotenoid intermediates in Neurospora crassa mutants imply a new biosynthetic reaction sequence leading to neurosporaxanthin formation". Fungal Genetics and Biology. 45 (11): 1497–505. doi:10.1016/j.fgb.2008.09.001. PMID 18812228.

External links

• Phytoene+desaturase+(3,4-didehydrolycopene-forming) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)