Phosphatidylethanolamine binding protein 1

Phosphatidylethanolamine-binding protein 1 is a protein that in humans is encoded by the PEBP1 gene.^[5][6]

PEBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BD9, 1BEH, 2L7W, 2QYQ
Identifiers
Aliases	PEBP1, HCNP, HCNPpp, HEL-210, HEL-S-34, PBP, PEBP, PEBP-1, RKIP, HEL-S-96, Phosphatidylethanolamine binding protein 1
External IDs	OMIM: 604591; MGI: 1344408; HomoloGene: 37637; GeneCards: PEBP1; OMA:PEBP1 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.23 Start 118,136,124 bp[1] End 118,145,584 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 F|5 56.88 cM Start 117,420,719 bp[2] End 117,425,690 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in renal medulla postcentral gyrus right adrenal cortex left adrenal gland left adrenal cortex internal globus pallidus superior frontal gyrus Brodmann area 9 prefrontal cortex superior vestibular nucleus Top expressed in testicle spermatid adrenal gland Mesencephalon proximal tubule spermatocyte neural tube dentate gyrus of hippocampal formation granule cell hippocampus proper lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding lipid binding nucleotide binding protein kinase binding phosphatidylethanolamine binding serine-type endopeptidase inhibitor activity ATP binding enzyme binding peptidase inhibitor activity RNA binding signaling receptor binding mitogen-activated protein kinase binding Cellular component cytoplasm cytosol nucleus extracellular exosome extracellular space mitochondrion mitochondrial outer membrane Golgi apparatus synaptic vesicle cell surface soma myelin sheath axon terminus apical part of cell Biological process MAPK cascade negative regulation of peptidase activity negative regulation of endopeptidase activity regulation of neurotransmitter levels regulation of the force of heart contraction response to oxidative stress ageing response to heat response to wounding response to toxic substance response to organonitrogen compound response to activity hippocampus development negative regulation of MAPK cascade positive regulation of cAMP-mediated signaling response to ethanol positive regulation of mitotic nuclear division sperm capacitation response to corticosterone response to cAMP response to calcium ion positive regulation of acetylcholine metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5037 23980 Ensembl ENSG00000089220 ENSMUSG00000032959 UniProt P30086 P70296 RefSeq (mRNA) NM_002567 NM_018858 RefSeq (protein) NP_002558 NP_061346 Location (UCSC) Chr 12: 118.14 – 118.15 Mb Chr 5: 117.42 – 117.43 Mb PubMed search [3] [4]
Wikidata
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Interactions

Phosphatidylethanolamine binding protein 1 has been shown to interact with:

• C-Raf,^[7]
• MAP2K1,^[7] and
• MAPK1.^[7]