Phaclofen

Phaclofen, or phosphonobaclofen, is a selective antagonist for the GABA_B receptor.^[1] It was the first selective GABA_B antagonist discovered, but its utility was limited by the fact that it does not cross the blood brain barrier.^[2]

Phaclofen

Names
IUPAC name [3-amino-2-(4-chlorophenyl)propyl]phosphonic acid
Identifiers
CAS Number	108351-35-5 Y
3D model (JSmol)	Interactive image
ChemSpider	1579 N
IUPHAR/BPS	1091
PubChem CID	1641
CompTox Dashboard (EPA)	DTXSID80871598
InChI InChI=1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14) N Key: VSGNGLJPOGUDON-UHFFFAOYSA-N N InChI=1/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14) Key: VSGNGLJPOGUDON-UHFFFAOYAO
SMILES C1=CC(=CC=C1C(CN)CP(=O)(O)O)Cl
Properties
Chemical formula	C9H13ClNO3P
Molar mass	249.631 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

References

1. Kerrn D, Ong J, Prager R, Gynther B, Curtis D (3 March 1987). "Phaclofen: a peripheral and central baclofen antagonist". Brain Research. 405 (1): 150–154. doi:10.1016/0006-8993(87)90999-1. PMID 3032346. S2CID 29595421.
2. Froestl W, Mickel SJ, von Sprecher G, Diel PJ, Hall RG, Maier L, Strub D, Melillo V, Baumann PA, Bernasconi R, et al. (August 18, 1995). "Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists". J Med Chem. 38 (17): 3313–3331. doi:10.1021/jm00017a016. PMID 7650685.