Pestivirus internal ribosome entry site (IRES)

This family represents the internal ribosome entry site (IRES) of the pestiviruses. The pestivirus IRES allows cap and end-independent translation of mRNA in the host cell. The IRES achieves this by mediating the internal initiation of translation by recruiting a ribosomal 43S pre-initiation complex directly to the initiation codon and eliminates the requirement for the eukaryotic initiation factor, eIF4F.^[1] The classical swine fever virus UTR described appears to be longer at the 5' end than other pestivirus UTRs.^[1] This family represents the conserved core.

Pestivirus internal ribosome entry site (IRES)
Predicted secondary structure and sequence conservation of IRES_Pesti
Identifiers
Symbol	IRES_Pesti
Alt. Symbols	Pesti_IRES
Rfam	RF00209
Other data
RNA type	Cis-reg; IRES
Domain(s)	Viruses
GO	GO:0043022
SO	SO:0000243
PDB structures	PDBe