Paramedian pontine reticular formation

The paramedian pontine reticular formation (PPRF) is a subset of neurons of the oral and caudal pontine reticular nuclei. With the abducens nucleus it makes up the horizontal gaze centre.^[1] It is situated in the pons adjacent to the abducens nucleus.^[2] It projects to the ipsilateral abducens (cranial nerve VI) nucleus, and contralateral oculomotor (cranial nerve III) nucleus^{[note 1]} to mediate conjugate horizontal gaze and saccades.

Paramedian pontine reticular formation
Axial section of the pons at the level of the facial colliculus (PPRF not labeled, but region is visible, near abducens nucleus)
Details
Part of	Brain stem
Artery	Pontine arteries
Vein	Transverse and lateral pontine veins
Identifiers
Latin	formatio reticularis pontis paramediana
NeuroNames	1399
Anatomical terms of neuroanatomy [edit on Wikidata]

Anatomy

The PPRF is situated in the pons just^[3] ventralmedial to the abducens nucleus.^[2] It is located anterior and lateral to the medial longitudinal fasciculus.^{[citation needed]} It is continuous caudally with the nucleus prepositus hypoglossi.^[4]

The PPRF (and adjacent regions of the pons) are traversed by fibers projecting to the abducens nucleus that mediate smooth pursuit, vestibular reflexes, and gaze holding.^[5]: 498

Afferents

The PPRF receives afferents from:

• contralateral frontal eye field of the middle frontal gyrus of the frontal lobe (via frontopontine fibers^[6] The frontal eye field meanwhile receives afferents from the visual cortex.^[7]
• superior colliculus^[6]
• vestibular nuclei^[6]
• other parts of the reticular formation.^[6]

Efferents

The PPRF mediates horizontal conjugate gaze (i.e. simultaneous horizontal movement of both eyes) by projecting to both:^[6][7]

• the ipsilateral abducens (CN VI) nucleus (which controls the ipsilateral lateral rectus muscle),
• (through the medial longitudinal fasciculus) the contralateral oculomotor (CN III) nucleus (specifically the population of its neurons that innervate the contralateral medial rectus muscle).

The pararaphal nucleus - one of distinct neuron population in the PPRF - projects to the flocculus of the cerebellum.^[5]: 498

Function

The PPRF mediates horizontal conjugate eye movements.^[3] It is important in mediating saccadic eye movements.^[2] It is probably not involved in smooth pursuit.^[2]

The PPRF generates excitatory bursts that are delivered to the ipsilateral abduecens nucleus to drive ipsilateral saccades (inhibitory saccadic stimuli are meanwhile delivered to the abducens nucleus from the contralateral medulla oblongata).^[5]: 499

Pathophysiology

Destructive lesions of the PPRF cause ipsilateral horizontal conjugate gaze palsy and mostly impair ipsilateral horizontal saccades, however, other horizontal and vertical eye movements may also be affected as the PPRF contains multiple distinct populations of neurons important in saccade generation, as well as being traversed by nerve fibers involved in eye movements that elsewhere; dysfunction of horizontal saccades will additionally also indirectly disrupt (slow and misdirect) vertical saccades^{[5]: 498-499} (though slowing of all saccades may also be accounted for by destruction of adjacent omnipause neurons of the interposited raphe nucleus^[5]: 221).

In the short-term, unilateral lesions of the PPRF may be characterised clinically by contralateral deviation of the eyes; looking contralaterally induces nystagmus characterised by quick twitches directed contralaterally whereas ipsilateral twitches are slow and do not move beyond the midline. More extensive lesions will also affect inhibition of antagonists, abolishing ipsilateral saccades.^[5]: 499

Clinical significance

Lesions of the medial pontine regions are relatively common. Due to the small size of the arteries in the area, the most common cause of a local lesion is an infarction due to lipohyalinosis and hypertension. Like other small arteries of the brain, these vessels are vulnerable to microemboli, especially those generated due to turbulence or low-flow states in those with artificial heart valves or arrhythmias, respectively.^[8] Unilateral lesions of the PPRF produce characteristic findings:

• Loss of horizontal saccades directed towards the side of the lesion, no matter the current position of gaze
• Contralateral gaze deviation (acute lesions, such as early stroke, only)
• Gaze-evoked lateral nystagmus on looking away from the side of the lesion
• Bilateral lesions produce horizontal gaze palsy and slowing of vertical saccades

See also

• Rostral interstitial nucleus of medial longitudinal fasciculus - vertical gaze center.
• Internuclear ophthalmoplegia
• One and a half syndrome
• Ophthalmoparesis
• Opsoclonus
• Saccade

Note

1. These two cranial nerve nuclei in turn control the ipsilateral lateral rectus muscle, and contralateral medial rectus muscle, respectively - their silmuntaneous contraction will thus cause both eyes to move ipsilaterally (i.e. towards the side of the PPRF in question).

References

1. Soleja, Mohsin; Almarzouqi, Sumayya J.; Morgan, Michael L.; Lee, Andrew G. (2016). "Horizontal Gaze Center". Encyclopedia of Ophthalmology: 1–2. doi:10.1007/978-3-642-35951-4_1286-1.
2. Brazis, Paul W.; Masdeu, Joseph C.; Biller, José (2022). Localization in Clinical Neurology (8th ed.). Philadelphia: Wolters Kluwer Health. ISBN 978-1-9751-6024-1.
3. Loftus, Brian D.; Athni, Sudhir S.; Cherches, Igor M. (2010), "Clinical Neuroanatomy", Neurology Secrets, Elsevier, p. 42, doi:10.1016/b978-0-323-05712-7.00002-7, ISBN 978-0-323-05712-7, retrieved 2024-07-17
4. Kiernan, John A.; Rajakumar, Nagalingam (2013). Barr's The Human Nervous System: An Anatomical Viewpoint (10th ed.). Philadelphia: Wolters Kluwer Lippincott Williams & Wilkins. p. 156. ISBN 978-1-4511-7327-7.
5. Leigh, R. John; Zee, David S. (1999). The Neurology of Eye Movements. Contemporary Neurology Series (3rd ed.). New York: Oxford University Press. ISBN 978-0-19-512972-4.
6. Patestas, Maria A.; Gartner, Leslie P. (2016). A Textbook of Neuroanatomy (2nd ed.). Hoboken, New Jersey: Wiley-Blackwell. p. 310. ISBN 978-1-118-67746-9.
7. Sinnatamby, Chummy S. (2011). Last's Anatomy (12th ed.). p. 404. ISBN 978-0-7295-3752-0.
8. Blumenfeld, Hal (2021). Neuroanatomy through Clinical Cases (3rd ed.). New York: Oxford University Press. p. 661. ISBN 978-1-60535-962-5.