Remove ads
A papilloma (plural papillomas or papillomata) (papillo- + -oma) is a benign epithelial tumor[1] growing exophytically (outwardly projecting) in nipple-like and often finger-like fronds. In this context, papilla refers to the projection created by the tumor, not a tumor on an already existing papilla (such as the nipple).
 | This article needs additional citations for verification. (May 2013) |
| Papilloma | |
|---|---|
 | |
| Intraductal papilloma of breast, H&E, 10x | |
| Specialty | Oncology  |
When used without context, it frequently refers to infections (squamous cell papilloma) caused by human papillomavirus (HPV), such as warts. Human papillomavirus infection is a major cause of cervical cancer, vulvar cancer, vaginal cancer, penis cancer, anal cancer, and HPV-positive oropharyngeal cancers.[2][3][4][5][6] Most viral warts are caused by human papillomavirus infection (HPV),[7] of which there are nearly 200 distinct human papillomaviruses (HPVs),[4] and many HPV types are carcinogenic.[2][3] There are, however, a number of other conditions that cause papilloma, as well as many cases in which there is no known cause.
Remove ads
HPV6 pedunculated papilloma behind the uvula and HPV6 sessile papilloma next to the uvula
HPV6 pedunculated papilloma removed from behind the uvula using a laser
A benign papillomatous tumor is derived from epithelium, with cauliflower-like projections that arise from the mucosal surface. It may appear white or normal colored. It may be pedunculated or sessile. The average size is between 1–5 cm. Neither sex is significantly more likely to develop them. The most common site is the palate-uvula area followed by tongue and lips. Durations range from weeks to 10 years.
Remove ads
Immunoperoxidase stains have identified antigens of the human papillomavirus (HPV) types 6 and 11 in approximately 50% of cases of squamous cell papilloma.[8]
There is no evidence that papillomas are premalignant.
- Intraoral verruca vulgaris,
- Condyloma acuminatum, and
- Focal epithelial hyperplasia.
Note: differentiation is done accurately by microscopic examination only.
With conservative surgical excision, recurrence is rare.[citation needed]
Wikiwand in your browser!
Seamless Wikipedia browsing. On steroids.
Every time you click a link to Wikipedia, Wiktionary or Wikiquote in your browser's search results, it will show the modern Wikiwand interface.
Wikiwand extension is a five stars, simple, with minimum permission required to keep your browsing private, safe and transparent.
Remove ads