Pancreatic polypeptide receptor 1

Pancreatic polypeptide receptor 1, also known as Neuropeptide Y receptor type 4, is a protein that in humans is encoded by the PPYR1 gene.^[5][6][7]

NPY4R
Identifiers
Aliases	NPY4R, NPY4-R, PP1, PPYR1, Y4, Pancreatic polypeptide receptor 1, neuropeptide Y receptor Y4
External IDs	OMIM: 601790; MGI: 105374; HomoloGene: 116086; GeneCards: NPY4R; OMA:NPY4R - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q11.22 Start 46,461,099 bp[1] End 46,465,958 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 B|14 20.8 cM Start 33,865,949 bp[2] End 33,874,446 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum transverse colon muscle layer of sigmoid colon duodenum mucosa of transverse colon smooth muscle tissue skin of abdomen skin of leg appendix stomach Top expressed in embryo lip urinary bladder digastric muscle stomach duodenum lumbar spinal ganglion jejunum ileum submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function neuropeptide Y receptor activity G protein-coupled receptor activity signal transducer activity pancreatic polypeptide receptor activity peptide hormone binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process signal transduction neuropeptide signaling pathway chemical synaptic transmission G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5540 19065 Ensembl ENSG00000204174 ENSMUSG00000048337 UniProt P0DQD5 P50391 Q61041 RefSeq (mRNA) NM_001278794 NM_005972 NM_008919 RefSeq (protein) NP_001265724 NP_001265723 NP_005963 NP_001265724 NP_032945 Location (UCSC) Chr 10: 46.46 – 46.47 Mb Chr 14: 33.87 – 33.87 Mb PubMed search [3] [4]
Wikidata
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Selective Ligands

Agonists

• Pancreatic polypeptide
• Neuropeptide Y (endogenous agonist, non subtype selective)
• Peptide YY
• GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Antagonists

• UR-AK49^[8]

See also

• Neuropeptide Y receptor