Pamiparib

Pamiparib
Clinical data
Trade names	Partruvix
Other names	BGB-290
ATC code	L01XK06 (WHO) ;
Legal status
Legal status	US: Investigational New Drug; Rx in China;
Identifiers
	IUPAC name (2R)-14-Fluoro-2-methyl-6,9,10,19-tetrazapentacyclo[14.2.1.02,6.08,18.012,17]nonadeca-1(18),8,12(17),13,15-pentaen-11-one;
CAS Number	1446261-44-4;
PubChem CID	135565554;
DrugBank	DB14769;
ChemSpider	58805610;
UNII	8375F9S90C;
KEGG	D11426;
ChEMBL	ChEMBL4112930;
Chemical and physical data
Formula	C16H15FN4O
Molar mass	298.321 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CCCN1CC3=NNC(=O)C4=C5C3=C2NC5=CC(=C4)F;
	InChI InChI=1S/C16H15FN4O/c1-16-3-2-4-21(16)7-11-13-12-9(15(22)20-19-11)5-8(17)6-10(12)18-14(13)16/h5-6,18H,2-4,7H2,1H3,(H,20,22)/t16-/m1/s1; Key:DENYZIUJOTUUNY-MRXNPFEDSA-N;

Pamiparib, sold under the brand name Partruvix, is a pharmaceutical drug used for the treatment of various types of cancer. Pamiparib is a member of the PARP inhibitor drug class.^[1]

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In China, it is approved for the treatment of germline BRCA mutation-associated recurrent advanced ovarian, fallopian tube, and primary peritoneal cancers previously treated with two or more lines of chemotherapy.^[2]

It is currently under investigation for the treatment of other forms of cancer.^[3]^[1]

[1]

[2]

[3]

Pamiparib

References

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