PTMS (gene)

Parathymosin is a protein that in humans is encoded by the PTMS gene.^[5][6]

PTMS
Identifiers
Aliases	PTMS, ParaT, parathymosin
External IDs	OMIM: 168440; MGI: 1916452; HomoloGene: 136762; GeneCards: PTMS; OMA:PTMS - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.31 Start 6,765,516 bp[1] End 6,770,952 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F2 Start 124,890,644 bp[2] End 124,897,066 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii right hemisphere of cerebellum right lobe of liver body of uterus ganglionic eminence muscle layer of sigmoid colon popliteal artery tibial arteries right ovary left ovary Top expressed in neural layer of retina dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus perirhinal cortex entorhinal cortex CA3 field ventricular zone lactiferous gland ascending aorta More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding Cellular component nucleus Biological process DNA replication immune system process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5763 69202 Ensembl ENSG00000159335 ENSMUSG00000030122 UniProt P20962 Q9D0J8 RefSeq (mRNA) NM_002824 NM_001330333 NM_026988 RefSeq (protein) NP_001317262 NP_002815 NP_081264 Location (UCSC) Chr 12: 6.77 – 6.77 Mb Chr 6: 124.89 – 124.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000159335 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030122 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Martic G, Karetsou Z, Kefala K, Politou AS, Clapier CR, Straub T, Papamarcaki T (Apr 2005). "Parathymosin affects the binding of linker histone H1 to nucleosomes and remodels chromatin structure". J Biol Chem. 280 (16): 16143–50. doi:10.1074/jbc.M410175200. PMID 15716277.
6. "Entrez Gene: PTMS parathymosin".

Further reading

• Hannappel E, Huff T (2003). "The thymosins. Prothymosin alpha, parathymosin, and beta-thymosins: structure and function". Vitam. Horm. 66: 257–96. doi:10.1016/s0083-6729(03)01007-0. PMID 12852257.
• Clinton M, Graeve L, el-Dorry H, et al. (1991). "Evidence for nuclear targeting of prothymosin and parathymosin synthesized in situ". Proc. Natl. Acad. Sci. U.S.A. 88 (15): 6608–12. Bibcode:1991PNAS...88.6608C. doi:10.1073/pnas.88.15.6608. PMC 52136. PMID 1862085.
• Panneerselvam C, Caldarella J, Horecker BL (1988). "A radioimmunoassay for parathymosin". J. Immunol. Methods. 104 (1–2): 131–6. doi:10.1016/0022-1759(87)90496-0. PMID 2445824.
• Clinton M, Frangou-Lazaridis M, Panneerselvam C, Horecker BL (1989). "The sequence of human parathymosin deduced from a cloned human kidney cDNA". Biochem. Biophys. Res. Commun. 158 (3): 855–62. doi:10.1016/0006-291X(89)92801-5. PMID 2537638.
• Szabo P, Clinton M, Macera M, Horecker BL (1989). "Localization of the gene coding for parathymosin to chromosome 17 in humans". Cytogenet. Cell Genet. 50 (2–3): 91–2. doi:10.1159/000132730. PMID 2776490.
• Kondili K, Tsolas O, Papamarcaki T (1997). "Selective interaction between parathymosin and histone H1". Eur. J. Biochem. 242 (1): 67–74. doi:10.1111/j.1432-1033.1996.0067r.x. PMID 8954154.
• Bruniquel D, Borie N, Triebel F (1998). "Genomic organization of the human LAG-3/CD4 locus". Immunogenetics. 47 (1): 96–8. doi:10.1007/s002510050332. PMID 9382927. S2CID 11259106.
• Okamoto K, Isohashi F (2000). "Purification and primary structure of a macromolecular-translocation inhibitor II of glucocorticoid-receptor binding to nuclei from rat liver. Inhibitor II is the 11.5-kDa Zn2+-binding protein (parathymosin)". Eur. J. Biochem. 267 (1): 155–62. doi:10.1046/j.1432-1327.2000.00987.x. PMID 10601862.
• Vareli K, Frangou-Lazaridis M, van der Kraan I, et al. (2000). "Nuclear distribution of prothymosin alpha and parathymosin: evidence that prothymosin alpha is associated with RNA synthesis processing and parathymosin with early DNA replication". Exp. Cell Res. 257 (1): 152–61. doi:10.1006/excr.2000.4857. PMID 10854063.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.