PRSS2

Protease, serine, 2 (trypsin 2) is a protein that in humans is encoded by the PRSS2 gene.^[5]

PRSS2
Identifiers
Aliases	PRSS2, TRY2, TRY8, TRYP2, protease, serine 2, serine protease 2
External IDs	OMIM: 601564; MGI: 102759; HomoloGene: 122141; GeneCards: PRSS2; OMA:PRSS2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q34 Start 142,760,398 bp[1] End 142,774,564 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B1 Start 41,498,721 bp[2] End 41,502,013 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans duodenum testicle fundus ectocervix right coronary artery body of stomach canal of the cervix right uterine tube Top expressed in pyloric antrum islet of Langerhans pancreatic acinus duodenum sexually immature organism mucous cell of stomach masseter muscle intercostal muscle brown adipose tissue quadriceps femoris muscle More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding peptidase activity protein binding hydrolase activity metal ion binding serine-type endopeptidase activity serine-type peptidase activity metalloendopeptidase activity Cellular component extracellular matrix extracellular region extracellular space azurophil granule lumen Biological process collagen catabolic process digestion positive regulation of cell growth extracellular matrix disassembly proteolysis positive regulation of cell adhesion antimicrobial humoral response neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5645 22072 Ensembl ENSG00000282049 ENSG00000275896 ENSMUSG00000057163 UniProt P07478 P07146 RefSeq (mRNA) NM_001303414 NM_002770 NM_009430 RefSeq (protein) NP_001290343 NP_002761 NP_033456 Location (UCSC) Chr 7: 142.76 – 142.77 Mb Chr 6: 41.5 – 41.5 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].