PRKCG

Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG gene.^[5][6]

PRKCG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2E73, 2UZP
Identifiers
Aliases	PRKCG, PKC-gamma, PKCC, PKCG, SCA14, protein kinase C gamma, PKCI(3), PKCgamma
External IDs	OMIM: 176980; MGI: 97597; HomoloGene: 20602; GeneCards: PRKCG; OMA:PRKCG - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.42 Start 53,879,190 bp[1] End 53,907,652 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A1|7 1.93 cM Start 3,337,704 bp[2] End 3,379,615 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe nucleus accumbens prefrontal cortex amygdala Brodmann area 9 cingulate gyrus anterior cingulate cortex caudate nucleus right hemisphere of cerebellum hippocampus proper Top expressed in hippocampus proper primary visual cortex dentate gyrus of hippocampal formation granule cell cerebellum cerebellar cortex Cortex of frontal lobe superior frontal gyrus striatum of neuraxis hypothalamus olfactory bulb More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity protein kinase activity nucleotide binding protein kinase C activity zinc ion binding metal ion binding kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity ATP binding calcium-dependent protein kinase C activity Cellular component cytoplasm synaptic membrane cytosol cell projection membrane cell-cell junction plasma membrane synapse intracellular anatomical structure cell junction dendrite perinuclear region of cytoplasm neuron projection nucleus postsynaptic density calyx of Held presynaptic cytosol postsynaptic cytosol Biological process negative regulation of neuron apoptotic process intracellular signal transduction phosphorylation negative regulation of protein catabolic process rhythmic process regulation of response to food platelet activation chemosensory behavior negative regulation of protein ubiquitination protein phosphorylation response to morphine positive regulation of mismatch repair response to pain regulation of circadian rhythm peptidyl-serine phosphorylation learning or memory protein autophosphorylation negative regulation of proteasomal protein catabolic process regulation of phagocytosis innervation chemical synaptic transmission response to psychosocial stress presynaptic modulation of chemical synaptic transmission regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5582 18752 Ensembl ENSG00000126583 ENSMUSG00000078816 UniProt P05129 P63318 RefSeq (mRNA) NM_002739 NM_001316329 NM_001291434 NM_011102 RefSeq (protein) NP_001303258 NP_002730 NP_001278363 NP_035232 Location (UCSC) Chr 19: 53.88 – 53.91 Mb Chr 7: 3.34 – 3.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).^[7]

Interactions

PRKCG has been shown to interact with GRIA4.^[8]

See also

• Protein kinase C

References

1. GRCh38: Ensembl release 89: ENSG00000126583 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000078816 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A, et al. (Mar 1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
6. Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A (Sep 1986). "Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways". Science. 233 (4766): 859–66. Bibcode:1986Sci...233..859C. doi:10.1126/science.3755548. PMID 3755548.
7. "Entrez Gene: PRKCG protein kinase C, gamma".
8. Correia, Susana Santos; Duarte Carlos Bandeira; Faro Carlos José; Pires Euclides Vieira; Carvalho Ana Luísa (Feb 2003). "Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation". J. Biol. Chem. 278 (8). United States: 6307–13. doi:10.1074/jbc.M205587200. hdl:10316/12633. ISSN 0021-9258. PMID 12471040.

Further reading

• Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.
• Slater SJ, Ho C, Stubbs CD (2003). "The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions". Chem. Phys. Lipids. 116 (1–2): 75–91. doi:10.1016/S0009-3084(02)00021-X. PMID 12093536.
• Saito N, Shirai Y (2003). "Protein kinase C gamma (PKC gamma): function of neuron specific isotype". J. Biochem. 132 (5): 683–7. doi:10.1093/oxfordjournals.jbchem.a003274. PMID 12417016.

External links

• GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 14