PPP1R9B

Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.^[5][6]

PPP1R9B
Identifiers
Aliases	PPP1R9B, PPP1R6, PPP1R9, SPINO, Spn, protein phosphatase 1 regulatory subunit 9B
External IDs	OMIM: 603325; MGI: 2387581; HomoloGene: 32787; GeneCards: PPP1R9B; OMA:PPP1R9B - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.33 Start 50,133,737 bp[1] End 50,150,677 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 94,881,861 bp[2] End 94,897,725 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum granulocyte cingulate gyrus anterior cingulate cortex monocyte right frontal lobe amygdala Brodmann area 9 prefrontal cortex nucleus accumbens Top expressed in dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex neural layer of retina granulocyte lip ventricular zone cerebellar cortex esophagus thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein phosphatase 1 binding protein binding protein phosphatase inhibitor activity actin binding actin filament binding Cellular component cytoplasm cell projection membrane filopodium adherens junction plasma membrane dendritic spine synapse nucleoplasm ruffle membrane cell junction protein phosphatase type 1 complex cytoskeleton nucleus lamellipodium postsynaptic density actin cytoskeleton dendrite Biological process cell differentiation regulation of opioid receptor signaling pathway filopodium assembly regulation of cell growth by extracellular stimulus modulation of chemical synaptic transmission nervous system development multicellular organism development regulation of cell population proliferation negative regulation of cell growth RNA splicing cellular response to morphine cell migration regulation of exit from mitosis negative regulation of phosphoprotein phosphatase activity actin filament organization calcium-mediated signaling neuron projection development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84687 217124 Ensembl ENSG00000108819 ENSMUSG00000038976 UniProt Q96SB3 Q6R891 RefSeq (mRNA) NM_032595 NM_172261 RefSeq (protein) NP_115984 NP_758465 Location (UCSC) Chr 17: 50.13 – 50.15 Mb Chr 11: 94.88 – 94.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997).[supplied by OMIM]^[6]

Interactions

PPP1R9B has been shown to interact with PPP1CB,^[7] PPP1CA,^[7] Dopamine receptor D2,^[8] P16,^[9] PPP1CC,^[7][8] T-cell lymphoma invasion and metastasis-inducing protein 1^[10] and PPP1R2.^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000108819 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038976 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Allen PB, Ouimet CC, Greengard P (Oct 1997). "Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines". Proc Natl Acad Sci U S A. 94 (18): 9956–61. Bibcode:1997PNAS...94.9956A. doi:10.1073/pnas.94.18.9956. PMC 23308. PMID 9275233.
6. "Entrez Gene: PPP1R9B protein phosphatase 1, regulatory (inhibitor) subunit 9B".
7. Hsieh-Wilson, L C; Allen P B; Watanabe T; Nairn A C; Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14). UNITED STATES: 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.
8. Smith, F D; Oxford G S; Milgram S L (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. 274 (28). UNITED STATES: 19894–900. doi:10.1074/jbc.274.28.19894. ISSN 0021-9258. PMID 10391935.
9. Vivo, M; Calogero R A; Sansone F; Calabrò V; Parisi T; Borrelli L; Saviozzi S; La Mantia G (Apr 2001). "The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein". J. Biol. Chem. 276 (17). United States: 14161–9. doi:10.1074/jbc.M006845200. ISSN 0021-9258. PMID 11278317.
10. Buchsbaum, Rachel J; Connolly Beth A; Feig Larry A (May 2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". J. Biol. Chem. 278 (21). United States: 18833–41. doi:10.1074/jbc.M207876200. ISSN 0021-9258. PMID 12531897.
11. Terry-Lorenzo, Ryan T; Elliot Elizabeth; Weiser Douglas C; Prickett Todd D; Brautigan David L; Shenolikar Shirish (Nov 2002). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". J. Biol. Chem. 277 (48). United States: 46535–43. doi:10.1074/jbc.M206960200. ISSN 0021-9258. PMID 12270929.

Further reading

• Burnett PE, Blackshaw S, Lai MM, et al. (1998). "Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton". Proc. Natl. Acad. Sci. U.S.A. 95 (14): 8351–6. Bibcode:1998PNAS...95.8351B. doi:10.1073/pnas.95.14.8351. PMC 20979. PMID 9653190.
• Hsieh-Wilson LC, Allen PB, Watanabe T, et al. (1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14): 4365–73. doi:10.1021/bi982900m. PMID 10194355.
• Smith FD, Oxford GS, Milgram SL (1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. 274 (28): 19894–900. doi:10.1074/jbc.274.28.19894. PMID 10391935.
• Stephens DJ, Banting G (1999). "Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin". J. Biol. Chem. 274 (42): 30080–6. doi:10.1074/jbc.274.42.30080. PMID 10514494.
• Richman JG, Brady AE, Wang Q, et al. (2001). "Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin". J. Biol. Chem. 276 (18): 15003–8. doi:10.1074/jbc.M011679200. PMID 11154706.
• Vivo M, Calogero RA, Sansone F, et al. (2001). "The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein". J. Biol. Chem. 276 (17): 14161–9. doi:10.1074/jbc.M006845200. PMID 11278317.
• Grossman SD, Hsieh-Wilson LC, Allen PB, et al. (2003). "The actin-binding domain of spinophilin is necessary and sufficient for targeting to dendritic spines". Neuromolecular Med. 2 (1): 61–9. doi:10.1385/NMM:2:1:61. PMID 12230305. S2CID 21825701.
• Terry-Lorenzo RT, Elliot E, Weiser DC, et al. (2003). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". J. Biol. Chem. 277 (48): 46535–43. doi:10.1074/jbc.M206960200. PMID 12270929.
• Hsieh-Wilson LC, Benfenati F, Snyder GL, et al. (2003). "Phosphorylation of spinophilin modulates its interaction with actin filaments". J. Biol. Chem. 278 (2): 1186–94. doi:10.1074/jbc.M205754200. PMID 12417592.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Buchsbaum RJ, Connolly BA, Feig LA (2003). "Regulation of p70 S6 kinase by complex formation between the Rac guanine nucleotide exchange factor (Rac-GEF) Tiam1 and the scaffold spinophilin". J. Biol. Chem. 278 (21): 18833–41. doi:10.1074/jbc.M207876200. PMID 12531897.
• Tsukada M, Prokscha A, Oldekamp J, Eichele G (2004). "Identification of neurabin II as a novel doublecortin interacting protein". Mech. Dev. 120 (9): 1033–43. doi:10.1016/S0925-4773(03)00177-1. PMID 14550532. S2CID 12470805.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Law AJ, Weickert CS, Hyde TM, et al. (2004). "Reduced spinophilin but not microtubule-associated protein 2 expression in the hippocampal formation in schizophrenia and mood disorders: molecular evidence for a pathology of dendritic spines". The American Journal of Psychiatry. 161 (10): 1848–55. doi:10.1176/appi.ajp.161.10.1848. PMID 15465982.