PPP1R3C

Protein phosphatase 1 regulatory subunit 3C also known as PTG is an enzyme that in humans is encoded by the PPP1R3C gene.^[5][6]

PPP1R3C
Identifiers
Aliases	PPP1R3C, PPP1R5, protein phosphatase 1 regulatory subunit 3C, PTG
External IDs	OMIM: 602999; MGI: 1858229; HomoloGene: 3938; GeneCards: PPP1R3C; OMA:PPP1R3C - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q23.32 Start 91,628,442 bp[1] End 91,633,071 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C2 Start 36,709,131 bp[2] End 36,714,053 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii vastus lateralis muscle triceps brachii muscle body of tongue glutes deltoid muscle tibialis anterior muscle vena cava saphenous vein Top expressed in sternocleidomastoid muscle triceps brachii muscle muscle of thigh digastric muscle intercostal muscle temporal muscle vastus lateralis muscle left lung lobe medial head of gastrocnemius muscle atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein serine/threonine phosphatase activity protein phosphatase regulator activity protein binding protein phosphatase binding Cellular component cytosol Biological process protein dephosphorylation glycogen biosynthetic process glycogen metabolic process carbohydrate metabolic process regulation of phosphoprotein phosphatase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5507 53412 Ensembl ENSG00000119938 ENSMUSG00000067279 UniProt Q9UQK1 Q7TMB3 RefSeq (mRNA) NM_005398 NM_016854 RefSeq (protein) NP_005389 NP_058550 Location (UCSC) Chr 10: 91.63 – 91.63 Mb Chr 19: 36.71 – 36.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Protein phosphatase-1 (PP1) participates in the regulation of a wide variety of cellular functions by reversible protein phosphorylation. The ability of PP1 to regulate diverse functions resides in its capacity to interact with a variety of regulatory subunits that may target PP1 to specific subcellular locations, modulate its substrate specificity, and allow its activity to be responsive to extracellular signals. Several targeting subunits of PP1 have been identified, including PPP1R5, the glycogen-binding subunits G_M, G_L, PTG and R6 and PPP1R4, and the nuclear inhibitor of PP1 (PPP1R8).^[6]