PPP1R13L

RelA-associated inhibitor is a protein that in humans is encoded by the PPP1R13L gene.^[5][6]

PPP1R13L
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VGE
Identifiers
Aliases	PPP1R13L, IASPP, NKIP1, RAI, RAI4, protein phosphatase 1 regulatory subunit 13 like
External IDs	OMIM: 607463; MGI: 3525053; HomoloGene: 84635; GeneCards: PPP1R13L; OMA:PPP1R13L - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 45,379,638 bp[1] End 45,406,349 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 A3|7 9.62 cM Start 19,093,674 bp[2] End 19,112,458 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg apex of heart left ventricle right auricle right coronary artery skin of thigh ascending aorta minor salivary glands skin of arm Top expressed in interventricular septum lip iris retinal pigment epithelium gastrula skin of abdomen cornea esophagus salivary gland submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription factor binding protein binding transcription corepressor activity identical protein binding cadherin binding Cellular component cell junction nucleus intercellular bridge nucleoplasm cytoplasm cytosol Biological process embryonic camera-type eye development hair cycle ventricular cardiac muscle tissue development regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II cardiac right ventricle morphogenesis post-embryonic development multicellular organismal homeostasis cardiac muscle contraction positive regulation of cell differentiation transcription, DNA-templated multicellular organism growth apoptotic process regulation of signal transduction by p53 class mediator Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10848 333654 Ensembl ENSG00000104881 ENSMUSG00000040734 UniProt Q8WUF5 Q5I1X5 RefSeq (mRNA) NM_006663 NM_001142502 NM_001010836 RefSeq (protein) NP_001135974 NP_006654 NP_001010836 Location (UCSC) Chr 19: 45.38 – 45.41 Mb Chr 7: 19.09 – 19.11 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

PPP1R13L has been shown to interact with Sp1 transcription factor^[7] and RELA.^[5][7]

References

1. GRCh38: Ensembl release 89: ENSG00000104881 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040734 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yang JP, Hori M, Sanda T, Okamoto T (May 1999). "Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor". The Journal of Biological Chemistry. 274 (22): 15662–70. doi:10.1074/jbc.274.22.15662. PMID 10336463.
6. "Entrez Gene: PPP1R13L protein phosphatase 1, regulatory (inhibitor) subunit 13 like".
7. Takada N, Sanda T, Okamoto H, Yang JP, Asamitsu K, Sarol L, Kimura G, Uranishi H, Tetsuka T, Okamoto T (August 2002). "RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions". Journal of Virology. 76 (16): 8019–30. doi:10.1128/JVI.76.16.8019-8030.2002. PMC 155123. PMID 12134007.

Further reading

• Liu ZJ, Lu X, Zhong S (September 2005). "ASPP--Apoptotic specific regulator of p53". Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1756 (1): 77–80. doi:10.1016/j.bbcan.2005.08.002. PMID 16139958.
• Takada N, Sanda T, Okamoto H, Yang JP, Asamitsu K, Sarol L, Kimura G, Uranishi H, Tetsuka T, Okamoto T (August 2002). "RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-kappaB and Sp1 actions". Journal of Virology. 76 (16): 8019–30. doi:10.1128/JVI.76.16.8019-8030.2002. PMC 155123. PMID 12134007.
• Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK, O'Connor DJ, Zhong S, Campargue I, Tomlinson ML, Kuwabara PE, Lu X (February 2003). "iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human". Nature Genetics. 33 (2): 162–7. doi:10.1038/ng1070. PMID 12524540. S2CID 22841392.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Slee EA, Gillotin S, Bergamaschi D, Royer C, Llanos S, Ali S, Jin B, Trigiante G, Lu X (December 2004). "The N-terminus of a novel isoform of human iASPP is required for its cytoplasmic localization". Oncogene. 23 (56): 9007–16. doi:10.1038/sj.onc.1208088. PMID 15489900.
• Issaeva N, Bozko P, Enge M, Protopopova M, Verhoef LG, Masucci M, Pramanik A, Selivanova G (December 2004). "Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors". Nature Medicine. 10 (12): 1321–8. doi:10.1038/nm1146. PMID 15558054. S2CID 82043.
• Zhang X, Wang M, Zhou C, Chen S, Wang J (February 2005). "The expression of iASPP in acute leukemias". Leukemia Research. 29 (2): 179–83. doi:10.1016/j.leukres.2004.07.001. PMID 15607367.
• Laska MJ, Nexø BA, Vistisen K, Poulsen HE, Loft S, Vogel U (July 2005). "Polymorphisms in RAI and in genes of nucleotide and base excision repair are not associated with risk of testicular cancer". Cancer Letters. 225 (2): 245–51. doi:10.1016/j.canlet.2005.03.021. PMID 15885892.
• Skjelbred CF, Saebø M, Nexø BA, Wallin H, Hansteen IL, Vogel U, Kure EH (July 2006). "Effects of polymorphisms in ERCC1, ASE-1 and RAI on the risk of colorectal carcinomas and adenomas: a case control study". BMC Cancer. 6: 175. doi:10.1186/1471-2407-6-175. PMC 1533843. PMID 16817948.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
• Bergamaschi D, Samuels Y, Sullivan A, Zvelebil M, Breyssens H, Bisso A, Del Sal G, Syed N, Smith P, Gasco M, Crook T, Lu X (October 2006). "iASPP preferentially binds p53 proline-rich region and modulates apoptotic function of codon 72-polymorphic p53". Nature Genetics. 38 (10): 1133–41. doi:10.1038/ng1879. PMID 16964264. S2CID 27662568.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Zhang X, Diao S, Rao Q, Xing H, Liu H, Liao X, Wang M, Wang J (May 2007). "Identification of a novel isoform of iASPP and its interaction with p53". Journal of Molecular Biology. 368 (4): 1162–71. doi:10.1016/j.jmb.2007.03.001. PMID 17391696.
• Laska MJ, Strandbygård D, Kjeldgaard A, Mains M, Corydon TJ, Memon AA, Sørensen BS, Vogel U, Jensen UB, Nexø BA (July 2007). "Expression of the RAI gene is conducive to apoptosis: studies of induction and interference". Experimental Cell Research. 313 (12): 2611–21. doi:10.1016/j.yexcr.2007.05.006. PMID 17570360.