POU2AF1

POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene.^[5][6] The protein is also termed Oct coactivator from B cells (i.e. OCAB), Oct binding factor 1 (OBF1 or OBF-1), and, as commonly found in the literature, BOB1.^[7] BOB1 is a transcriptional coactivator (i.e. a protein that controls the activity of transcription factors) which is expressed principally by B-cell lymphocytes and controls immunoglobulin and other genes critical for these cells expression of CD20, CRISP-3, and CD36.^[8] The expression of BOB1 has proven useful for identifying certain lymphomas as being B-cell lymphomas,^[9] as exemplified in studies which use BOB1 expression to help identify lymphomas as being diffuse large B-cell lymphomas, not otherwise specified.^[10]

POU2AF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CQT
Identifiers
Aliases	POU2AF1, BOB1, OBF-1, OBF1, OCAB, POU class 2 associating factor 1, POU class 2 homeobox associating factor 1
External IDs	OMIM: 601206; MGI: 105086; HomoloGene: 4543; GeneCards: POU2AF1; OMA:POU2AF1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.1 Start 111,352,255 bp[1] End 111,455,630 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 A5.3 Start 51,125,008 bp[2] End 51,151,380 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx pylorus cardia spleen lymph node appendix bronchial epithelial cell tonsil bone marrow cells mucosa of ileum Top expressed in spleen mesenteric lymph nodes submandibular gland blood tibiofemoral joint female urethra tunica adventitia of aorta granulocyte subcutaneous adipose tissue duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription coactivator activity protein binding transcription coregulator activity RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus RNA polymerase II transcription regulator complex Biological process regulation of transcription, DNA-templated humoral immune response transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5450 18985 Ensembl ENSG00000110777 ENSMUSG00000032053 UniProt Q16633 Q64693 RefSeq (mRNA) NM_006235 NM_011136 RefSeq (protein) NP_006226 NP_035266 Location (UCSC) Chr 11: 111.35 – 111.46 Mb Chr 9: 51.13 – 51.15 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

POU2AF1 has been shown to interact with:

• POU2F1^[11][12][13] and
• SIAH1.^[14][15]

See also

• POU domain
• POU domain class 2 transcription factors:
  • POU2F1, POU2F2, POU2F3