POU2AF1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

POU2AF1

POU domain class 2-associating factor 1 is a protein that in humans is encoded by the POU2AF1 gene.[5][6] The protein is also termed Oct coactivator from B cells (i.e. OCAB), Oct binding factor 1 (OBF1 or OBF-1), and, as commonly found in the literature, BOB1.[7] BOB1 is a transcriptional coactivator (i.e. a protein that controls the activity of transcription factors) which is expressed principally by B-cell lymphocytes and controls immunoglobulin and other genes critical for these cells expression of CD20, CRISP-3, and CD36.[8] The expression of BOB1 has proven useful for identifying certain lymphomas as being B-cell lymphomas,[9] as exemplified in studies which use BOB1 expression to help identify lymphomas as being diffuse large B-cell lymphomas, not otherwise specified.[10]

Quick Facts Available structures, PDB ...
POU2AF1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOU2AF1, BOB1, OBF-1, OBF1, OCAB, POU class 2 associating factor 1, POU class 2 homeobox associating factor 1
External IDsOMIM: 601206; MGI: 105086; HomoloGene: 4543; GeneCards: POU2AF1; OMA:POU2AF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006235

NM_011136

RefSeq (protein)

NP_006226

NP_035266

Location (UCSC)Chr 11: 111.35 – 111.46 MbChr 9: 51.13 – 51.15 Mb
PubMed search[3][4]
Wikidata
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Interactions

POU2AF1 has been shown to interact with:

See also

References

Further reading

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