POLR2J2

DNA directed RNA polymerase II polypeptide J-related gene, also known as POLR2J2, is a human gene.^[3]

POLR2J2
Identifiers
Aliases	POLR2J2, polymerase (RNA) II (DNA directed) polypeptide J2, HRPB11B, RPB11b1, polymerase (RNA) II subunit J2, RNA polymerase II subunit J2, RPB11b2, POLR2J3
External IDs	OMIM: 609881; HomoloGene: 129653; GeneCards: POLR2J2; OMA:POLR2J2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 102,665,368 bp[1] End 102,671,629 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad blood stromal cell of endometrium mucosa of transverse colon sural nerve monocyte bone marrow cells granulocyte spleen n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity DNA binding protein dimerization activity RNA polymerase II activity Cellular component nucleus RNA polymerase II, core complex Biological process transcription, DNA-templated transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 246721 n/a Ensembl ENSG00000228049 n/a UniProt Q9GZM3 n/a RefSeq (mRNA) NM_145325 NM_032958 NM_032959 n/a RefSeq (protein) NP_001091084 NP_116581 n/a Location (UCSC) Chr 7: 102.67 – 102.67 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J.

Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.^[3]

References

1. GRCh38: Ensembl release 89: ENSG00000228049 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: POLR2J2 DNA directed RNA polymerase II polypeptide J-related gene".

Further reading

• Shpakovskii DG, Shematorova EK, Shpakovskii GV (2006). "Human PMS2 gene family: origin, molecular evolution, and biological implications". Dokl. Biochem. Biophys. 408: 175–179. doi:10.1134/S1607672906030185. PMID 16913423. S2CID 30897463.
• Benga WJ, Grandemange S, Shpakovski GV, et al. (2005). "Distinct regions of RPB11 are required for heterodimerization with RPB3 in human and yeast RNA polymerase II". Nucleic Acids Res. 33 (11): 3582–3590. doi:10.1093/nar/gki672. PMC 1159119. PMID 15987790.
• Shpakovskiĭ DG, Shematorova EK, Shpakovskiĭ GV (2005). "[New genes on human chromosome 7: bioinformatic analysis of a gene cluster from the POLR2J family]". Bioorg. Khim. 30 (6): 621–5. doi:10.1023/b:rubi.0000049773.14555.4c. PMID 15586814. S2CID 1452697.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Durrin LK, Krontiris TG (2002). "The thymocyte-specific MAR binding protein, SATB1, interacts in vitro with a novel variant of DNA-directed RNA polymerase II, subunit 11". Genomics. 79 (6): 809–817. doi:10.1006/geno.2002.6772. PMID 12036295.
• Grandemange S, Schaller S, Yamano S, et al. (2003). "A human RNA polymerase II subunit is encoded by a recently generated multigene family". BMC Mol. Biol. 2: 14. doi:10.1186/1471-2199-2-14. PMC 61041. PMID 11747469.
• Cramer P, Bushnell DA, Fu J, et al. (2000). "Architecture of RNA polymerase II and implications for the transcription mechanism". Science. 288 (5466): 640–649. Bibcode:2000Sci...288..640C. doi:10.1126/science.288.5466.640. hdl:11858/00-001M-0000-0015-872F-3. PMID 10784442.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.