POLE2

DNA polymerase epsilon subunit 2 is an enzyme that in humans is encoded by the POLE2 gene.^[5][6][7]

POLE2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V6Z
Identifiers
Aliases	POLE2, DPE2, polymerase (DNA) epsilon 2, accessory subunit, DNA polymerase epsilon 2, accessory subunit
External IDs	OMIM: 602670; MGI: 1197514; HomoloGene: 2015; GeneCards: POLE2; OMA:POLE2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q21.3 Start 49,643,555 bp[1] End 49,688,422 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 C2 Start 69,248,547 bp[2] End 69,274,969 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad testicle ventricular zone secondary oocyte mucosa of transverse colon rectum ganglionic eminence right uterine tube mucosa of esophagus ectocervix Top expressed in tongue muscle choroidal fissure zygote tail of embryo spermatid genital tubercle blastocyst embryo morula ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity DNA binding nucleotidyltransferase activity protein binding DNA-directed DNA polymerase activity Cellular component intracellular membrane-bounded organelle nucleus nucleoplasm nuclear body epsilon DNA polymerase complex Biological process DNA repair error-prone translesion synthesis DNA replication DNA-dependent DNA replication G1/S transition of mitotic cell cycle DNA replication initiation telomere maintenance via semi-conservative replication Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5427 18974 Ensembl ENSG00000100479 ENSMUSG00000020974 UniProt P56282 O54956 RefSeq (mRNA) NM_001197330 NM_001197331 NM_002692 NM_001348384 NM_001348385 NM_011133 RefSeq (protein) NP_001184259 NP_001184260 NP_002683 NP_001335313 NP_001335314 NP_035263 Location (UCSC) Chr 14: 49.64 – 49.69 Mb Chr 12: 69.25 – 69.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Interactions

POLE2 has been shown to interact with SAP18.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000100479 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020974 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Li Y, Asahara H, Patel VS, Zhou S, Linn S (Jan 1998). "Purification, cDNA cloning, and gene mapping of the small subunit of human DNA polymerase epsilon". J Biol Chem. 272 (51): 32337–44. doi:10.1074/jbc.272.51.32337. PMID 9405441.
6. Jokela M, Mäkiniemi M, Lehtonen S, Szpirer C, Hellman U, Syväoja JE (Mar 1998). "The small subunits of human and mouse DNA polymerase epsilon are homologous to the second largest subunit of the yeast Saccharomyces cerevisiae DNA polymerase epsilon". Nucleic Acids Res. 26 (3): 730–4. doi:10.1093/nar/26.3.730. PMC 147316. PMID 9443964.
7. "Entrez Gene: POLE2 polymerase (DNA directed), epsilon 2 (p59 subunit)".
8. Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (Mar 2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". J. Biochem. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.

Further reading

• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
• Post SM, Tomkinson AE, Lee EY (2003). "The human checkpoint Rad protein Rad17 is chromatin-associated throughout the cell cycle, localizes to DNA replication sites, and interacts with DNA polymerase ε". Nucleic Acids Res. 31 (19): 5568–75. doi:10.1093/nar/gkg765. PMC 206465. PMID 14500819.
• Wada M, Miyazawa H, Wang RS, Mizuno T, Sato A, Asashima M, Hanaoka F (2002). "The second largest subunit of mouse DNA polymerase epsilon, DPE2, interacts with SAP18 and recruits the Sin3 co-repressor protein to DNA". J. Biochem. 131 (3): 307–11. doi:10.1093/oxfordjournals.jbchem.a003104. PMID 11872158.
• Huang D, Jokela M, Tuusa J, Skog S, Poikonen K, Syväoja JE (2001). "E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase ɛ B-subunit gene POLE2". Nucleic Acids Res. 29 (13): 2810–21. doi:10.1093/nar/29.13.2810. PMC 55767. PMID 11433027.
• Li Y, Pursell ZF, Linn S (2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J. Biol. Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA polymerase epsilon subunit 2 (POLE2)