POLDIP3

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.^[5][6]

POLDIP3
Identifiers
Aliases	POLDIP3, PDIP46, SKAR, polymerase (DNA) delta interacting protein 3, DNA polymerase delta interacting protein 3, PDIP3
External IDs	OMIM: 611520; MGI: 1921076; HomoloGene: 13007; GeneCards: POLDIP3; OMA:POLDIP3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 42,583,721 bp[1] End 42,614,962 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 83,010,177 bp[2] End 83,033,585 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence left ovary oocyte right ovary granulocyte right uterine tube islet of Langerhans cardia body of uterus Top expressed in internal carotid artery external carotid artery motor neuron condyle Rostral migratory stream fossa medial ganglionic eminence ascending aorta aortic valve vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding protein-containing complex binding Cellular component exon-exon junction complex transcription export complex nucleus nuclear speck cytoplasm cytosol nucleoplasm cytoplasmic ribonucleoprotein granule Biological process poly(A)+ mRNA export from nucleus mRNA transport regulation of translation positive regulation of translation termination of RNA polymerase II transcription mRNA 3'-end processing RNA export from nucleus mRNA export from nucleus transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84271 73826 Ensembl ENSG00000100227 ENSMUSG00000041815 UniProt Q9BY77 Q8WUT1 Q8BG81 RefSeq (mRNA) NM_001278657 NM_032311 NM_178136 NM_001363052 NM_178627 NM_001347082 RefSeq (protein) NP_001265586 NP_115687 NP_835237 NP_001349981 NP_001334011 NP_848742 Location (UCSC) Chr 22: 42.58 – 42.61 Mb Chr 15: 83.01 – 83.03 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.^[6]

Interactions

POLDIP3 has been shown to interact with P70-S6 Kinase 1.^[7]