POLDIP3

Polymerase delta-interacting protein 3 is an enzyme that in humans is encoded by the POLDIP3 gene.^[5][6]

POLDIP3
Identifiers
Aliases	POLDIP3, PDIP46, SKAR, polymerase (DNA) delta interacting protein 3, DNA polymerase delta interacting protein 3, PDIP3
External IDs	OMIM: 611520; MGI: 1921076; HomoloGene: 13007; GeneCards: POLDIP3; OMA:POLDIP3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.2 Start 42,583,721 bp[1] End 42,614,962 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 E1 Start 83,010,177 bp[2] End 83,033,585 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence left ovary oocyte right ovary granulocyte right uterine tube islet of Langerhans cardia body of uterus Top expressed in internal carotid artery external carotid artery motor neuron condyle Rostral migratory stream fossa medial ganglionic eminence ascending aorta aortic valve vestibular membrane of cochlear duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding nucleic acid binding RNA binding protein-containing complex binding Cellular component exon-exon junction complex transcription export complex nucleus nuclear speck cytoplasm cytosol nucleoplasm cytoplasmic ribonucleoprotein granule Biological process poly(A)+ mRNA export from nucleus mRNA transport regulation of translation positive regulation of translation termination of RNA polymerase II transcription mRNA 3'-end processing RNA export from nucleus mRNA export from nucleus transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 84271 73826 Ensembl ENSG00000100227 ENSMUSG00000041815 UniProt Q9BY77 Q8WUT1 Q8BG81 RefSeq (mRNA) NM_001278657 NM_032311 NM_178136 NM_001363052 NM_178627 NM_001347082 RefSeq (protein) NP_001265586 NP_115687 NP_835237 NP_001349981 NP_001334011 NP_848742 Location (UCSC) Chr 22: 42.58 – 42.61 Mb Chr 15: 83.01 – 83.03 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified.^[6]

Interactions

POLDIP3 has been shown to interact with P70-S6 Kinase 1.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000100227 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041815 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Liu L, Rodriguez-Belmonte EM, Mazloum N, Xie B, Lee MY (Mar 2003). "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen". J Biol Chem. 278 (12): 10041–7. doi:10.1074/jbc.M208694200. PMID 12522211.
6. "Entrez Gene: POLDIP3 polymerase (DNA-directed), delta interacting protein 3".
7. Richardson CJ, Bröenstrup Mark, Fingar Diane C, Jülich Kristina, Ballif Bryan A, Gygi Steven, Blenis John (Sep 2004). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. 14 (17). England: 1540–9. Bibcode:2004CBio...14.1540R. doi:10.1016/j.cub.2004.08.061. ISSN 0960-9822. PMID 15341740.

Further reading

• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Hirosawa M, Nagase T, Murahashi Y, et al. (2001). "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping". DNA Res. 8 (1): 1–9. CiteSeerX 10.1.1.321.2497. doi:10.1093/dnares/8.1.1. PMID 11258795.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Collins JE, Goward ME, Cole CG, et al. (2003). "Reevaluating human gene annotation: a second-generation analysis of chromosome 22". Genome Res. 13 (1): 27–36. doi:10.1101/gr.695703. PMC 430954. PMID 12529303.
• Richardson CJ, Bröenstrup M, Fingar DC, et al. (2005). "SKAR is a specific target of S6 kinase 1 in cell growth control". Curr. Biol. 14 (17): 1540–9. Bibcode:2004CBio...14.1540R. doi:10.1016/j.cub.2004.08.061. PMID 15341740.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Smyk A, Szuminska M, Uniewicz KA, et al. (2006). "Human enhancer of rudimentary is a molecular partner of PDIP46/SKAR, a protein interacting with DNA polymerase delta and S6K1 and regulating cell growth". FEBS J. 273 (20): 4728–41. doi:10.1111/j.1742-4658.2006.05477.x. PMID 16984396.