PNRC1

Proline-rich nuclear receptor coactivator 1 is a protein that, in humans, is encoded by the PNRC1 gene.^[5][6]

PNRC1
Identifiers
Aliases	PNRC1, B4-2, PNAS-145, PROL2, PRR2, proline rich nuclear receptor coactivator 1
External IDs	OMIM: 606714; MGI: 1917838; HomoloGene: 4960; GeneCards: PNRC1; OMA:PNRC1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q15 Start 89,080,751 bp[1] End 89,085,160 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 33,245,423 bp[2] End 33,290,163 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gastric mucosa left uterine tube gastrocnemius muscle left ovary muscle of thigh right ovary tibial arteries epithelium of colon gallbladder Top expressed in left lung lobe medial ganglionic eminence granulocyte lymph node mesenteric lymph nodes lacrimal gland molar thoracic diaphragm submandibular gland digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component P-body nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated nuclear-transcribed mRNA catabolic process, nonsense-mediated decay deadenylation-independent decapping of nuclear-transcribed mRNA Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10957 108767 Ensembl ENSG00000146278 ENSMUSG00000040128 UniProt Q12796 Q49A59 Q3TWH3 RefSeq (mRNA) NM_006813 NM_001033225 RefSeq (protein) NP_006804 NP_001028397 Location (UCSC) Chr 6: 89.08 – 89.09 Mb Chr 4: 33.25 – 33.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

PNRC1 functions as a coactivator for several nuclear receptors including AR, ERα, ERRα, ERRγ, GR, SF1, PR, TR, RAR and RXR.^[7][8] The interaction between PNRC1 with nuclear receptors occurs through the SH3 domain of PNRC1.^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000146278 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000040128 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen J, Liu L, Pohajdak B (Dec 1995). "Cloning a cDNA from human NK/T cells which codes for a protein with high proline content". Biochim Biophys Acta. 1264 (1): 19–22. doi:10.1016/0167-4781(95)00159-e. PMID 7578250.
6. "Entrez Gene: PNRC1 proline-rich nuclear receptor coactivator 1".
7. Zhou D, Quach KM, Yang C, Lee SY, Pohajdak B, Chen S (July 2000). "PNRC: a proline-rich nuclear receptor coregulatory protein that modulates transcriptional activation of multiple nuclear receptors including orphan receptors SF1 (steroidogenic factor 1) and ERRalpha1 (estrogen related receptor alpha-1)". Mol. Endocrinol. 14 (7): 986–98. doi:10.1210/mend.14.7.0480. PMID 10894149.
8. Zhou D, Chen S (October 2001). "PNRC2 is a 16 kDa coactivator that interacts with nuclear receptors through an SH3-binding motif". Nucleic Acids Res. 29 (19): 3939–48. doi:10.1093/nar/29.19.3939. PMC 60244. PMID 11574675.

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Zhou D, Chen B, Ye JJ, Chen S (2004). "A novel crosstalk mechanism between nuclear receptor-mediated and growth factor/Ras-mediated pathways through PNRC-Grb2 interaction". Oncogene. 23 (31): 5394–404. doi:10.1038/sj.onc.1207695. PMID 15122321.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hsiao PW, Chang C (1999). "Isolation and characterization of ARA160 as the first androgen receptor N-terminal-associated coactivator in human prostate cells". J. Biol. Chem. 274 (32): 22373–9. CiteSeerX 10.1.1.621.2877. doi:10.1074/jbc.274.32.22373. PMID 10428808. S2CID 15532327.

External links

• PNRC1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• NURSA C108