PLXND1

Plexin-D1 is a protein that in humans is encoded by the PLXND1 gene.^[5][6]

PLXND1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3H6N
Identifiers
Aliases	PLXND1, PLEXD1, plexin D1
External IDs	OMIM: 604282; MGI: 2154244; HomoloGene: 22866; GeneCards: PLXND1; OMA:PLXND1 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.1 Start 129,555,214 bp[1] End 129,606,676 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 E3 Start 115,931,772 bp[2] End 115,971,966 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in upper lobe of left lung right coronary artery right lung tibial nerve canal of the cervix apex of heart body of uterus left uterine tube gallbladder left coronary artery Top expressed in thymus external carotid artery ankle joint molar lumbar spinal ganglion internal carotid artery yolk sac atrium genital tubercle decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein domain specific binding protein binding semaphorin receptor activity Cellular component integral component of membrane membrane plasma membrane lamellipodium integral component of plasma membrane lamellipodium membrane cell projection semaphorin receptor complex Biological process cardiac septum development outflow tract morphogenesis regulation of angiogenesis coronary vasculature development multicellular organism development aorta development angiogenesis dichotomous subdivision of terminal units involved in salivary gland branching branching involved in blood vessel morphogenesis synapse assembly positive regulation of protein binding endothelial cell migration semaphorin-plexin signaling pathway signal transduction negative regulation of cell adhesion regulation of cell shape regulation of cell migration positive regulation of axonogenesis regulation of GTPase activity positive regulation of transcription of Notch receptor target semaphorin-plexin signaling pathway involved in axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23129 67784 Ensembl ENSG00000004399 ENSMUSG00000030123 UniProt Q9Y4D7 Q3UH93 RefSeq (mRNA) NM_015103 NM_026376 RefSeq (protein) NP_055918 NP_080652 Location (UCSC) Chr 3: 129.56 – 129.61 Mb Chr 6: 115.93 – 115.97 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000004399 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030123 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. van der Zwaag B, Hellemons AJ, Leenders WP, Burbach JP, Brunner HG, Padberg GW, Van Bokhoven H (Nov 2002). "PLEXIN-D1, a novel plexin family member, is expressed in vascular endothelium and the central nervous system during mouse embryogenesis". Dev Dyn. 225 (3): 336–43. doi:10.1002/dvdy.10159. PMID 12412018. S2CID 36110289.
6. "Entrez Gene: PLXND1 plexin D1".

Further reading

• Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro" (PDF). DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
• Tamagnone L, Artigiani S, Chen H, et al. (1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gitler AD, Lu MM, Epstein JA (2004). "PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development". Dev. Cell. 7 (1): 107–16. doi:10.1016/j.devcel.2004.06.002. PMID 15239958.
• van der Zwaag B, Verzijl HT, Wichers KH, et al. (2004). "Sequence analysis of the PLEXIN-D1 gene in Möbius syndrome patients". Pediatr. Neurol. 31 (2): 114–8. doi:10.1016/j.pediatrneurol.2004.02.004. PMID 15301830.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.