PLCB2

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an enzyme that in humans is encoded by the PLCB2 gene.^[5][6][7]

PLCB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2FJU, 2ZKM
Identifiers
Aliases	PLCB2, PLC-beta-2, phospholipase C beta 2
External IDs	OMIM: 604114; MGI: 107465; HomoloGene: 20957; GeneCards: PLCB2; OMA:PLCB2 - orthologs
Gene location (Human) Chr. Chromosome 15 (human)[1] Band 15q15.1 Start 40,278,176 bp[1] End 40,307,935 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 E5|2 59.43 cM Start 118,537,998 bp[2] End 118,558,919 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte spleen blood bone marrow cells lymph node appendix upper lobe of left lung right lung C1 segment Top expressed in granulocyte thymus female urethra male urethra lumbar subsegment of spinal cord blood spermatocyte spleen ascending aorta aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoric diester hydrolase activity phospholipase C activity calcium ion binding hydrolase activity signal transducer activity metal ion binding phosphatidylinositol phospholipase C activity Cellular component cytoplasm cytosol Biological process lipid catabolic process sensory perception of bitter taste phospholipid metabolic process intracellular signal transduction inositol phosphate metabolic process activation of phospholipase C activity signal transduction lipid metabolism Wnt signaling pathway, calcium modulating pathway G protein-coupled receptor signaling pathway inositol trisphosphate biosynthetic process phosphatidylinositol-mediated signaling release of sequestered calcium ion into cytosol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5330 18796 Ensembl ENSG00000137841 ENSMUSG00000040061 UniProt Q00722 A3KGF7 RefSeq (mRNA) NM_001284297 NM_001284298 NM_001284299 NM_004573 NM_001290790 NM_177568 RefSeq (protein) NP_001271226 NP_001271227 NP_001271228 NP_004564 NP_001277719 NP_808236 Location (UCSC) Chr 15: 40.28 – 40.31 Mb Chr 2: 118.54 – 118.56 Mb PubMed search [3] [4]
Wikidata
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Function

The gene codes for the enzyme phospholipase C β2. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions

PLCB2 has been shown to interact with MAP2K3^[8] and TRPM7.^[9]