PKNOX1

PBX/Knotted 1 Homeobox 1 (PKNOX1) is a protein that in humans is encoded by the PKNOX1 gene.^[5][6]

PKNOX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1X2N
Identifiers
Aliases	PKNOX1, PREP1, pkonx1c, PBX/knotted 1 homeobox 1
External IDs	OMIM: 602100; MGI: 1201409; HomoloGene: 3363; GeneCards: PKNOX1; OMA:PKNOX1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 42,974,510 bp[1] End 43,033,931 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17 B1|17 16.78 cM Start 31,783,708 bp[2] End 31,826,667 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad right lobe of thyroid gland testicle left testis right testis left lobe of thyroid gland ganglionic eminence ventricular zone sural nerve stromal cell of endometrium Top expressed in Rostral migratory stream granulocyte vas deferens thymus internal carotid artery efferent ductule spermatocyte human fetus blood external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding sequence-specific DNA binding DNA binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific protein binding Cellular component cytoplasm nucleus transcription regulator complex cytosol Biological process erythrocyte differentiation regulation of transcription by RNA polymerase II camera-type eye development T cell differentiation regulation of transcription, DNA-templated angiogenesis positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5316 18771 Ensembl ENSG00000160199 ENSMUSG00000006705 UniProt P55347 Q96I87 O70477 RefSeq (mRNA) NM_001286258 NM_004571 NM_001320694 NM_197976 NM_016670 RefSeq (protein) NP_001273187 NP_001307623 NP_004562 NP_001273187.1 NP_004562.2 NP_001307623.1 NP_057879 Location (UCSC) Chr 21: 42.97 – 43.03 Mb Chr 17: 31.78 – 31.83 Mb PubMed search [3] [4]
Wikidata
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An important paralog of this gene is PKNOX2.

Function

PKNOX1 belongs to the three amino acid loop extension (TALE) class of homeodomain transcription factors that form transcriptionally active complexes involved in development and organogenesis. PKNOX1 is essential for embryogenesis, but it can also act as a tumor suppressor in adulthood.^[7]

See also: Homeobox