PFN2

Profilin-2 is a protein that in humans is encoded by the PFN2 gene.^[4][5][6]

PFN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D1J
Identifiers
Aliases	PFN2, D3S1319E, PFL, profilin 2
External IDs	OMIM: 176590; MGI: 97550; HomoloGene: 1974; GeneCards: PFN2; OMA:PFN2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q25.1 Start 149,964,904 bp[1] End 150,050,788 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in frontal pole superior frontal gyrus postcentral gyrus Brodmann area 10 Pons middle temporal gyrus orbitofrontal cortex ganglionic eminence glutes ventricular zone n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding phosphatidylinositol-4,5-bisphosphate binding actin monomer binding protein binding ATPase activity Cellular component cytoplasm terminal bouton extracellular exosome cytoskeleton Schaffer collateral - CA1 synapse presynapse postsynapse glutamatergic synapse Biological process regulation of actin filament polymerization regulation of synaptic vesicle exocytosis protein stabilization positive regulation of actin filament bundle assembly positive regulation of actin filament polymerization negative regulation of actin filament polymerization positive regulation of ATP-dependent activity negative regulation of epithelial cell migration positive regulation of stress fiber assembly actin cytoskeleton organization positive regulation of peptidyl-serine phosphorylation negative regulation of ruffle assembly modification of postsynaptic actin cytoskeleton Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5217 18645 Ensembl ENSG00000070087 ENSMUSG00000027805 UniProt P35080 Q9JJV2 RefSeq (mRNA) NM_053024 NM_002628 NM_019410 RefSeq (protein) NP_002619 NP_444252 NP_062283 Location (UCSC) Chr 3: 149.96 – 150.05 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene.^[6]

Interactions

PFN2 has been shown to interact with ROCK1,^[7] Vasodilator-stimulated phosphoprotein,^[8][9] CCDC113^[10] and FMNL1.^[11]