PF-06260414

PF-06260414 is a drug which acts as a selective androgen receptor modulator (SARM), and was developed for androgen replacement therapy.^[1][2][3]

PF-06260414

Legal status
Legal status	US: Investigational new drug
Identifiers
IUPAC name 6-[(4R)-4-methyl-1,1-dioxo-1,2,6-thiadiazinan-2-yl]isoquinoline-1-carbonitrile
CAS Number	1612755-71-1
PubChem CID	76071881
DrugBank	DB15221
ChemSpider	58824307
UNII	3I487UHH95
ChEMBL	ChEMBL4297476
Chemical and physical data
Formula	C14H14N4O2S
Molar mass	302.35 g·mol−1
3D model (JSmol)	Interactive image
SMILES C[C@@H]1CNS(=O)(=O)N(C1)C2=CC3=C(C=C2)C(=NC=C3)C#N
InChI InChI=1S/C14H14N4O2S/c1-10-8-17-21(19,20)18(9-10)12-2-3-13-11(6-12)4-5-16-14(13)7-15/h2-6,10,17H,8-9H2,1H3/t10-/m1/s1 Key:ZKAVFOXYJCREBQ-SNVBAGLBSA-N

See also

• AC-262536
• ACP-105
• Enobosarm
• JNJ-28330835
• Ligandrol

References

1. Bhattacharya I, Tarabar S, Liang Y, Pradhan V, Owens J, Oemar B (June 2016). "Safety, Pharmacokinetic, and Pharmacodynamic Evaluation After Single and Multiple Ascending Doses of a Novel Selective Androgen Receptor Modulator in Healthy Subjects". Clinical Therapeutics. 38 (6): 1401–1416. doi:10.1016/j.clinthera.2016.03.025. PMID 27085586.
2. Ventura E, Gadaj A, Buckley T, Mooney MH (September 2020). "Development of a multi-residue high-throughput UHPLC-MS/MS method for routine monitoring of SARM compounds in equine and bovine blood". Drug Testing and Analysis. 12 (9): 1373–1379. doi:10.1002/dta.2875. PMID 32519780. S2CID 219563612.
3. Cutler C, Viljanto M, Taylor P, Hincks P, Biddle S, Van Eenoo P (October 2021). "Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes". Drug Testing and Analysis. 14 (2): 349–370. doi:10.1002/dta.3189. hdl:1854/LU-8740373. PMID 34714606. S2CID 240152623.