PERP

p53 apoptosis effector related to PMP-22 is a plasma membrane protein that, in humans, is encoded by the PERP gene.^[5][6]

PERP
Identifiers
Aliases	PERP, KCP1, KRTCAP1, PIGPC1, THW, dJ496H19.1, TP53 apoptosis effector, p53 apoptosis effector related to PMP22, EKVP7, OLMS2
External IDs	OMIM: 609301; MGI: 1929938; HomoloGene: 11098; GeneCards: PERP; OMA:PERP - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.3 Start 138,088,505 bp[1] End 138,107,419 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A3 Start 18,720,768 bp[2] End 18,732,821 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in human penis skin of thigh mucosa of pharynx nipple skin of hip vulva oral cavity gingival epithelium body of tongue epithelium of nasopharynx Top expressed in corneal stroma epidermis hair follicle skin of external ear lip skin of back transitional epithelium of urinary bladder skin of abdomen molar esophagus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 64065 64058 Ensembl ENSG00000112378 ENSMUSG00000019851 UniProt Q96FX8 Q9JK95 RefSeq (mRNA) NM_022121 NM_022032 RefSeq (protein) NP_071404 NP_071315 Location (UCSC) Chr 6: 138.09 – 138.11 Mb Chr 10: 18.72 – 18.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

PERP is a direct transcriptional target of p53, but its transcription can also be regulated by other transcription factors.^[7]

PERP is important for skin development, and loss of PERP is associated with the development and progression of several types of human cancers.^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000112378 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019851 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hildebrandt T, Preiherr J, Tarbe N, Klostermann S, Van Muijen GN, Weidle UH (Dec 2000). "Identification of THW, a putative new tumor suppressor gene". Anticancer Res. 20 (5A): 2801–2809. PMID 11062687.
6. "Entrez Gene: PERP PERP, TP53 apoptosis effector".
7. Roberts O, Paraoan L (Dec 2020). "PERP-ing into diverse mechanisms of cancer pathogenesis: Regulation and role of the p53/p63 effector PERP". Biochim Biophys Acta Rev Cancer. 1874 (1): 188393. doi:10.1016/j.bbcan.2020.188393. PMID 32679166. S2CID 220631324.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Attardi LD, Reczek EE, Cosmas C, et al. (2000). "PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family". Genes Dev. 14 (6): 704–718. doi:10.1101/gad.14.6.704. PMC 316461. PMID 10733530.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bonkobara M, Das A, Takao J, et al. (2003). "Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes". Br. J. Dermatol. 148 (4): 654–664. doi:10.1046/j.1365-2133.2003.05244.x. PMID 12752121. S2CID 21635573.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–811. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Ihrie RA, Attardi LD (2004). "Perp-etrating p53-dependent apoptosis". Cell Cycle. 3 (3): 267–269. doi:10.4161/cc.3.3.722. PMID 14726658.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.