PERP

p53 apoptosis effector related to PMP-22 is a plasma membrane protein that, in humans, is encoded by the PERP gene.^[5][6]

PERP
Identifiers
Aliases	PERP, KCP1, KRTCAP1, PIGPC1, THW, dJ496H19.1, TP53 apoptosis effector, p53 apoptosis effector related to PMP22, EKVP7, OLMS2
External IDs	OMIM: 609301; MGI: 1929938; HomoloGene: 11098; GeneCards: PERP; OMA:PERP - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.3 Start 138,088,505 bp[1] End 138,107,419 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A3 Start 18,720,768 bp[2] End 18,732,821 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in human penis skin of thigh mucosa of pharynx nipple skin of hip vulva oral cavity gingival epithelium body of tongue epithelium of nasopharynx Top expressed in corneal stroma epidermis hair follicle skin of external ear lip skin of back transitional epithelium of urinary bladder skin of abdomen molar esophagus More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 64065 64058 Ensembl ENSG00000112378 ENSMUSG00000019851 UniProt Q96FX8 Q9JK95 RefSeq (mRNA) NM_022121 NM_022032 RefSeq (protein) NP_071404 NP_071315 Location (UCSC) Chr 6: 138.09 – 138.11 Mb Chr 10: 18.72 – 18.73 Mb PubMed search [3] [4]
Wikidata
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PERP is a direct transcriptional target of p53, but its transcription can also be regulated by other transcription factors.^[7]

PERP is important for skin development, and loss of PERP is associated with the development and progression of several types of human cancers.^[7]