PDGFA

Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene.^[5][6]

PDGFA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MJK
Identifiers
Aliases	PDGFA, PDGF-A, PDGF1, platelet derived growth factor subunit A
External IDs	OMIM: 173430; MGI: 97527; HomoloGene: 32055; GeneCards: PDGFA; OMA:PDGFA - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p22.3 Start 497,258 bp[1] End 520,296 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 G2|5 77.65 cM Start 138,961,769 bp[2] End 138,983,125 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell ascending aorta Descending thoracic aorta right coronary artery body of pancreas popliteal artery tibial arteries left coronary artery optic nerve C1 segment Top expressed in Ileal epithelium choroid plexus of fourth ventricle calvaria choroidal fissure entorhinal cortex tunica media of zone of aorta iris retinal pigment epithelium perirhinal cortex CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function collagen binding protein homodimerization activity platelet-derived growth factor receptor binding protein binding platelet-derived growth factor binding protein heterodimerization activity growth factor activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity identical protein binding Cellular component endoplasmic reticulum lumen membrane Golgi membrane extracellular region microvillus cell surface platelet alpha granule lumen extracellular space Golgi lumen Biological process hair follicle development embryonic lung development positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway negative chemotaxis regulation of actin cytoskeleton organization positive regulation of MAP kinase activity regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling positive regulation of cell migration positive regulation of fibroblast proliferation cell-cell signaling platelet degranulation extracellular matrix organization regulation of DNA biosynthetic process cell activation MAPK cascade negative regulation of platelet activation multicellular organism development positive regulation of mesenchymal cell proliferation response to wounding cell projection assembly negative regulation of phosphatidylinositol biosynthetic process angiogenesis positive regulation of protein autophosphorylation positive regulation of ERK1 and ERK2 cascade regulation of smooth muscle cell migration animal organ morphogenesis positive regulation of phosphatidylinositol 3-kinase signaling platelet-derived growth factor receptor signaling pathway lung alveolus development positive regulation of cell division actin cytoskeleton organization positive regulation of MAPK cascade skin development regulation of glomerular mesangial cell proliferation regulation of peptidyl-tyrosine phosphorylation wound healing phosphatidylinositol phosphate biosynthetic process positive regulation of cell population proliferation regulation of signaling receptor activity positive regulation of protein kinase B signaling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5154 18590 Ensembl ENSG00000197461 ENSMUSG00000025856 UniProt P04085 P20033 RefSeq (mRNA) NM_002607 NM_033023 NM_001395363 NM_001395364 NM_001395365 NM_001395366 NM_008808 NM_001363271 RefSeq (protein) NP_002598 NP_148983 NP_032834 NP_001350200 Location (UCSC) Chr 7: 0.5 – 0.52 Mb Chr 5: 138.96 – 138.98 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene.^[7]