PDE7B

PDE7B is a mammalian gene that encodes a 3'5'-cyclic nucleotide phosphodiesterase (PDE) that converts 3'5'-cyclic adenosine monophosphate (cAMP) to 5'AMP as part of cyclic nucleotide signaling pathways.^[5][6] There are 21 PDE genes in mammals that are pharmacologically-grouped into 11 families based on their biochemical characteristics and sequence conservation. The PDE7 family is composed of PDEs encoded by two genes, PDE7A and PDE7B. These PDEs are highly specific for cAMP relative to cGMP.

PDE7B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LXW
Identifiers
Aliases	PDE7B, bA472E5.1, phosphodiesterase 7B
External IDs	OMIM: 604645; MGI: 1352752; HomoloGene: 32194; GeneCards: PDE7B; OMA:PDE7B - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q23.3 Start 135,851,701 bp[1] End 136,195,574 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 A3 Start 20,273,750 bp[2] End 20,600,824 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in germinal epithelium Achilles tendon external globus pallidus nucleus accumbens middle temporal gyrus buccal mucosa cell tibia caudate nucleus putamen endothelial cell Top expressed in olfactory tubercle globus pallidus olfactory epithelium lateral geniculate nucleus medial dorsal nucleus nucleus accumbens vas deferens median eminence medial geniculate nucleus extraocular muscle More reference expression data BioGPS n/a
Gene ontology Molecular function 3',5'-cyclic-AMP phosphodiesterase activity phosphoric diester hydrolase activity hydrolase activity 3',5'-cyclic-nucleotide phosphodiesterase activity metal ion binding Cellular component cytosol Biological process cAMP catabolic process signal transduction chemical synaptic transmission G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27115 29863 Ensembl ENSG00000171408 ENSMUSG00000019990 UniProt Q9NP56 Q9QXQ1 RefSeq (mRNA) NM_018945 NM_013875 NM_001347366 RefSeq (protein) NP_061818 NP_001334295 NP_038903 Location (UCSC) Chr 6: 135.85 – 136.2 Mb Chr 10: 20.27 – 20.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000171408 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019990 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hetman, J.M., Soderling, S.H., Glavas, N.A., and Beavo, J.A. (2000). Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc Natl Acad Sci U S A 97, 472-476.
6. Sasaki, T., Kotera, J., Yuasa, K., and Omori, K. (2000). Identification of human PDE7B, a cAMP-specific phosphodiesterase. Biochem Biophys Res Commun 271, 575-583.