PARP8

Poly [ADP-ribose] polymerase 8 is an enzyme that in humans is encoded by the PARP8 gene.^[5][6]

PARP8
Identifiers
Aliases	PARP8, ARTD16, pART16, poly(ADP-ribose) polymerase family member 8
External IDs	MGI: 1098713; HomoloGene: 11621; GeneCards: PARP8; OMA:PARP8 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q11.1 Start 50,665,899 bp[1] End 50,846,519 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13 D2.3|13 65.32 cM Start 116,991,356 bp[2] End 117,162,073 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte blood spleen left lobe of thyroid gland bone marrow cells right lobe of thyroid gland gallbladder right uterine tube epithelium of colon Top expressed in morula morula granulocyte tail of embryo intervertebral disc islet of Langerhans spermatid zygote genital tubercle secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity NAD+ ADP-ribosyltransferase activity transferase activity protein ADP-ribosylase activity Cellular component intracellular anatomical structure Biological process metabolism protein ADP-ribosylation protein auto-ADP-ribosylation protein mono-ADP-ribosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79668 52552 Ensembl ENSG00000151883 ENSMUSG00000021725 UniProt Q8N3A8 Q3UD82 RefSeq (mRNA) NM_001178055 NM_001178056 NM_024615 NM_001331028 NM_001081009 NM_027272 RefSeq (protein) NP_001171526 NP_001171527 NP_001317957 NP_078891 NP_001074478 Location (UCSC) Chr 5: 50.67 – 50.85 Mb Chr 13: 116.99 – 117.16 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

References

1. GRCh38: Ensembl release 89: ENSG00000151883 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021725 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ame JC, Spenlehauer C, de Murcia G (Jul 2004). "The PARP superfamily". BioEssays. 26 (8): 882–93. doi:10.1002/bies.20085. PMID 15273990. S2CID 25024719.
6. "Entrez Gene: PARP8 poly (ADP-ribose) polymerase family, member 8".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.