PAPOLA

Poly(A) polymerase alpha is an enzyme that in humans is encoded by the PAPOLA gene.^[5][6][7]

PAPOLA
Identifiers
Aliases	PAPOLA, PAP, poly(A) polymerase alpha, PAP-alpha
External IDs	OMIM: 605553; MGI: 109301; HomoloGene: 23389; GeneCards: PAPOLA; OMA:PAPOLA - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q32.2 Start 96,501,433 bp[1] End 96,567,116 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 E Start 105,750,953 bp[2] End 105,805,203 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon Epithelium of choroid plexus ventricular zone ganglionic eminence Achilles tendon mucosa of sigmoid colon bone marrow cells body of pancreas endometrium jejunal mucosa Top expressed in genital tubercle tail of embryo yolk sac ventricular zone neural layer of retina abdominal wall dermis islet of Langerhans spermatid decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding nucleotidyltransferase activity manganese ion binding metal ion binding protein binding RNA binding ATP binding magnesium ion binding polynucleotide adenylyltransferase activity Cellular component cytoplasm nucleoplasm nucleus Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription RNA 3'-end processing mRNA processing mRNA polyadenylation mRNA 3'-end processing regulation of mRNA 3'-end processing RNA polyadenylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10914 18789 Ensembl ENSG00000090060 ENSMUSG00000021111 UniProt P51003 Q61183 RefSeq (mRNA) NM_001252006 NM_001252007 NM_001293627 NM_001293628 NM_001293632 NM_032632 NM_001363662 NM_001363664 NM_001363665 NM_001363666 NM_011112 NM_001347440 RefSeq (protein) NP_001238935 NP_001238936 NP_001280556 NP_001280557 NP_001280561 NP_116021 NP_001350591 NP_001350593 NP_001350594 NP_001350595 NP_001334369 NP_035242 Location (UCSC) Chr 14: 96.5 – 96.57 Mb Chr 12: 105.75 – 105.81 Mb PubMed search [3] [4]
Wikidata
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PAPOLA binds to FIP1L1 (Factor interacting with PAPOLA and CPSF1), a subunit of the cleavage and polyadenylation specificity factor subunit 1 (CPSF1) complex. This complex polyadenylates the 3' end of precursor mRNAs (pre-mRNA) (see CPSF). CPSF1 is an RNA processing protein that binds to uracil-rich sequences in pre-mRNA, binds with and stimulates PAPOLA's Polynucleotide adenylyltransferase activity, and thereby adds adenylyl residues to pre-mRNA. This poly-adenylyl action increases pre mRNA's maturation and movement from the nucleus to cytoplasm while dramatically increasing the stability of the mRNA formed from pre-mRNA: FIP1L1 is a Pre-mRNA 3'-end-processing factor. FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or Retinoic acid receptor alpha (RARA) genes are causes of certain human diseases associated with pathologically increased levels of blood eosinophils and/or Leukemias.^[8]