P2RY6

P2Y purinoceptor 6 is a protein that in humans is encoded by the P2RY6 gene.^[5][6]

P2RY6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2B6R
Identifiers
Aliases	P2RY6, P2Y6, pyrimidinergic receptor P2Y6
External IDs	OMIM: 602451; MGI: 2673874; HomoloGene: 14289; GeneCards: P2RY6; OMA:P2RY6 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 73,264,498 bp[1] End 73,305,103 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 100,586,837 bp[2] End 100,623,856 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen placenta right coronary artery left coronary artery gonad appendix human kidney muscle of thigh thoracic aorta ascending aorta Top expressed in stroma of bone marrow ascending aorta aortic valve mesenteric lymph nodes calvaria left colon tunica media of zone of aorta ankle internal carotid artery subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled purinergic nucleotide receptor activity G protein-coupled receptor activity protein binding G protein-coupled UDP receptor activity signal transducer activity G protein-coupled ADP receptor activity G protein-coupled UTP receptor activity Cellular component integral component of membrane plasma membrane basolateral plasma membrane integral component of plasma membrane apical plasma membrane membrane Biological process positive regulation of smooth muscle cell migration phospholipase C-activating G protein-coupled receptor signaling pathway cellular response to organic cyclic compound transepithelial chloride transport signal transduction G protein-coupled purinergic nucleotide receptor signaling pathway cellular response to prostaglandin E stimulus G protein-coupled receptor signaling pathway positive regulation of ERK1 and ERK2 cascade positive regulation of vascular associated smooth muscle cell proliferation phagocytosis activation of phospholipase C activity positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity positive regulation of inositol trisphosphate biosynthetic process cellular response to purine-containing compound cellular response to pyrimidine ribonucleotide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5031 233571 Ensembl ENSG00000171631 ENSMUSG00000048779 UniProt Q15077 Q9ERK9 RefSeq (mRNA) NM_001277204 NM_001277205 NM_001277206 NM_001277207 NM_001277208 NM_004154 NM_176796 NM_176797 NM_176798 NM_183168 RefSeq (protein) NP_001264133 NP_001264134 NP_001264135 NP_001264136 NP_001264137 NP_789766 NP_789767 NP_789768 NP_898991 Location (UCSC) Chr 11: 73.26 – 73.31 Mb Chr 7: 100.59 – 100.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The product of this gene, P2Y₆, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene.^[6]

See also

• P2Y receptor

References

1. GRCh38: Ensembl release 89: ENSG00000171631 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000048779 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Communi D, Parmentier M, Boeynaems JM (May 1996). "Cloning, functional expression and tissue distribution of the human P2Y6 receptor". Biochemical and Biophysical Research Communications. 222 (2): 303–8. doi:10.1006/bbrc.1996.0739. PMID 8670200.
6. "Entrez Gene: P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6".

Further reading

• Maier R, Glatz A, Mosbacher J, Bilbe G (Aug 1997). "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues". Biochemical and Biophysical Research Communications. 237 (2): 297–302. doi:10.1006/bbrc.1997.7135. PMID 9268704.
• Somers GR, Hammet F, Woollatt E, Richards RI, Southey MC, Venter DJ (Aug 1997). "Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family". Genomics. 44 (1): 127–30. doi:10.1006/geno.1997.4841. PMID 9286708.
• Pidlaoan LV, Jin J, Sandhu AK, Athwal RS, Kunapuli SP (Jul 1997). "Colocalization of P2Y2 and P2Y6 receptor genes at human chromosome 11q13.3-14.1". Somatic Cell and Molecular Genetics. 23 (4): 291–6. doi:10.1007/BF02674420. PMID 9542531. S2CID 24535480.
• Brinson AE, Harden TK (Apr 2001). "Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor". The Journal of Biological Chemistry. 276 (15): 11939–48. doi:10.1074/jbc.M009909200. PMID 11114308.
• Moore DJ, Chambers JK, Wahlin JP, Tan KB, Moore GB, Jenkins O, Emson PC, Murdock PR (Oct 2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1521 (1–3): 107–19. doi:10.1016/S0167-4781(01)00291-3. PMID 11690642.
• Hou M, Harden TK, Kuhn CM, Baldetorp B, Lazarowski E, Pendergast W, Möller S, Edvinsson L, Erlinge D, Schmoldt A, Benthe HF, Haberland G, Klimpel GR, Day KD, Lucas DO, Kalyanaraman VS, Mahadevan S, Kumar SA, Wachter RF, Briggs GP, Pedersen CE, Nozaki M, Bose KS, Sarma RH, Granström G, Linde A (Feb 2002). "UDP acts as a growth factor for vascular smooth muscle cells by activation of P2Y6 receptors". Am J Physiol Heart Circ Physiol. 282 (2): H784–92. doi:10.1152/ajpheart.00997.2000. PMID 11788430. S2CID 19082766.
• Loomis WH, Namiki S, Ostrom RS, Insel PA, Junger WG (Feb 2003). "Hypertonic stress increases T cell interleukin-2 expression through a mechanism that involves ATP release, P2 receptor, and p38 MAPK activation". The Journal of Biological Chemistry. 278 (7): 4590–6. doi:10.1074/jbc.M207868200. PMID 12464620.
• Kim SG, Soltysiak KA, Gao ZG, Chang TS, Chung E, Jacobson KA (Mar 2003). "Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors". Biochemical Pharmacology. 65 (6): 923–31. doi:10.1016/S0006-2952(02)01614-3. PMC 3402349. PMID 12623123.
• Schafer R, Sedehizade F, Welte T, Reiser G (Aug 2003). "ATP- and UTP-activated P2Y receptors differently regulate proliferation of human lung epithelial tumor cells". American Journal of Physiology. Lung Cellular and Molecular Physiology. 285 (2): L376–85. doi:10.1152/ajplung.00447.2002. PMID 12691958. S2CID 108677.
• Lee H, Choi BH, Suh BC, Lee SK, Kim KT (May 2003). "Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells". Journal of Neurochemistry. 85 (4): 1043–53. doi:10.1046/j.1471-4159.2003.01761.x. PMID 12716436. S2CID 24830829.
• Wan D, Gong Y, Qin W, Zhang P, Li J, Wei L, Zhou X, Li H, Qiu X, Zhong F, He L, Yu J, Yao G, Jiang H, Qian L, Yu Y, Shu H, Chen X, Xu H, Guo M, Pan Z, Chen Y, Ge C, Yang S, Gu J (Nov 2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proceedings of the National Academy of Sciences of the United States of America. 101 (44): 15724–9. Bibcode:2004PNAS..10115724W. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Cox MA, Gomes B, Palmer K, Du K, Wiekowski M, Wilburn B, Petro M, Chou CC, Desquitado C, Schwarz M, Lunn C, Lundell D, Narula SK, Zavodny PJ, Jenh CH (May 2005). "The pyrimidinergic P2Y6 receptor mediates a novel release of proinflammatory cytokines and chemokines in monocytic cells stimulated with UDP". Biochemical and Biophysical Research Communications. 330 (2): 467–73. doi:10.1016/j.bbrc.2005.03.004. PMID 15796906.
• Khine AA, Del Sorbo L, Vaschetto R, Voglis S, Tullis E, Slutsky AS, Downey GP, Zhang H (Apr 2006). "Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway". Blood. 107 (7): 2936–42. doi:10.1182/blood-2005-06-2314. hdl:1807/17906. PMID 16322472.
• Wihlborg AK, Balogh J, Wang L, Borna C, Dou Y, Joshi BV, Lazarowski E, Jacobson KA, Arner A, Erlinge D (Apr 2006). "Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction". Circulation Research. 98 (7): 970–6. doi:10.1161/01.RES.0000217402.73402.cd. PMC 3492942. PMID 16543499.
• Dulong S, Bernard K, Ehrenfeld J (2007). "Enhancement of P2Y6-induced Cl- secretion by IL-13 and modulation of SK4 channels activity in human bronchial cells". Cellular Physiology and Biochemistry. 20 (5): 483–94. doi:10.1159/000107532. PMID 17762175.

External links

• "P2Y Receptors: P2Y₆". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2015-02-17. Retrieved 2008-12-09.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.