P2RX5

P2X purinoceptor 5 is a protein in humans that is encoded by the P2RX5 gene.^[5][6]

P2RX5
Identifiers
Aliases	P2RX5, LRH-1, P2X5, P2X5R, purinergic receptor P2X 5
External IDs	OMIM: 602836; MGI: 2137026; HomoloGene: 1924; GeneCards: P2RX5; OMA:P2RX5 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 3,672,199 bp[1] End 3,696,240 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 73,051,247 bp[2] End 73,063,511 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in spleen lymph node appendix granulocyte mucosa of ileum blood apex of heart gastrocnemius muscle bone marrow cells glutes Top expressed in brown adipose tissue soleus muscle masseter muscle facial motor nucleus ascending aorta intercostal muscle myocardium of ventricle motor neuron muscle of thigh proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function ion channel activity ATP binding transmembrane signaling receptor activity purinergic nucleotide receptor activity extracellularly ATP-gated cation channel activity ATP-gated ion channel activity Cellular component integral component of membrane integral component of nuclear inner membrane integral component of plasma membrane membrane plasma membrane cytosol postsynapse Biological process response to ATP positive regulation of calcium-mediated signaling ion transport positive regulation of calcium ion transport into cytosol cation transmembrane transport signal transduction nervous system development blood coagulation purinergic nucleotide receptor signaling pathway excitatory postsynaptic potential cation transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5026 94045 Ensembl ENSG00000083454 ENSMUSG00000005950 UniProt Q93086 n/a RefSeq (mRNA) NM_175081 NM_001204519 NM_001204520 NM_002561 NM_175080 NM_033321 NM_001376982 NM_001376983 RefSeq (protein) NP_001191448 NP_001191449 NP_002552 NP_778255 n/a Location (UCSC) Chr 17: 3.67 – 3.7 Mb Chr 11: 73.05 – 73.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Four transcript variants encoding distinct isoforms have been identified for this gene.^[6]

See also

• P2X receptor

References

1. GRCh38: Ensembl release 89: ENSG00000083454 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005950 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Le KT, Paquet M, Nouel D, Babinski K, Seguela P (Jan 1998). "Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system". FEBS Lett. 418 (1–2): 195–9. doi:10.1016/S0014-5793(97)01380-X. PMID 9414125. S2CID 42070561.
6. "Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5".

Further reading

• North RA (2002). "Molecular physiology of P2X receptors". Physiol. Rev. 82 (4): 1013–67. doi:10.1152/physrev.00015.2002. PMID 12270951.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Touchman JW, Anikster Y, Dietrich NL, et al. (2000). "The genomic region encompassing the nephropathic cystinosis gene (CTNS): complete sequencing of a 200-kb segment and discovery of a novel gene within the common cystinosis-causing deletion". Genome Res. 10 (2): 165–73. doi:10.1101/gr.10.2.165. PMC 310836. PMID 10673275.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
• Greig AV, Linge C, Terenghi G, et al. (2003). "Purinergic receptors are part of a functional signaling system for proliferation and differentiation of human epidermal keratinocytes". J. Invest. Dermatol. 120 (6): 1007–15. doi:10.1046/j.1523-1747.2003.12261.x. PMID 12787128.
• Greig AV, Linge C, Healy V, et al. (2003). "Expression of purinergic receptors in non-melanoma skin cancers and their functional roles in A431 cells". J. Invest. Dermatol. 121 (2): 315–27. doi:10.1046/j.1523-1747.2003.12379.x. PMID 12880424.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• de Rijke B, van Horssen-Zoetbrood A, Beekman JM, et al. (2006). "A frameshift polymorphism in P2X5 elicits an allogeneic cytotoxic T lymphocyte response associated with remission of chronic myeloid leukemia". J. Clin. Invest. 115 (12): 3506–16. doi:10.1172/JCI24832. PMC 1297240. PMID 16322791.
• Metcalfe MJ, Baker DM, Burnstock G (2007). "Purinoceptor expression on keratinocytes reflects their function on the epidermis during chronic venous insufficiency". Arch. Dermatol. Res. 298 (6): 301–7. doi:10.1007/s00403-006-0693-x. PMID 16967306. S2CID 11545279.
• Duckwitz W, Hausmann R, Aschrafi A, Schmalzing G (2007). "P2X5 subunit assembly requires scaffolding by the second transmembrane domain and a conserved aspartate". J. Biol. Chem. 281 (51): 39561–72. doi:10.1074/jbc.M606113200. hdl:2066/130384. PMID 17001079.

External links

• P2RX5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.