Oxyclozanide

Chemical compound From Wikipedia, the free encyclopedia

Oxyclozanide

Oxyclozanide is a salicylanilide anthelmintic. It is used in the treatment and control of fascioliasis in ruminants, mainly domestic animals such as cattle, sheep, and goats. It mainly acts by uncoupling of oxidative phosphorylation in flukes.[1] Along with niclosamide, another tapeworm drug, it has been recently found to display "strong in vivo and in vitro activity against methicillin-resistant Staphylococcus aureus (MRSA)".[2]

Quick Facts Names, Identifiers ...
Oxyclozanide
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Names
Preferred IUPAC name
2,3,5-Trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.017.186
KEGG
UNII
  • InChI=1S/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22) N
    Key: JYWIYHUXVMAGLG-UHFFFAOYSA-N N
  • InChI=1/C13H6Cl5NO3/c14-4-1-6(16)11(20)8(2-4)19-13(22)9-10(18)5(15)3-7(17)12(9)21/h1-3,20-21H,(H,19,22)
    Key: JYWIYHUXVMAGLG-UHFFFAOYAW
  • C1=C(C=C(C(=C1Cl)O)NC(=O)C2=C(C(=CC(=C2Cl)Cl)Cl)O)Cl
Properties
C13H6Cl5NO3
Molar mass 401.45 g·mol−1
Pharmacology
QP52AG06 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YN ?)
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Sometimes alluded to as "Pentaclosamide": CN101891646.

References

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