OTX1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

OTX1

Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene.[5][6]

Quick Facts Identifiers, Aliases ...
OTX1
Identifiers
AliasesOTX1, orthodenticle homeobox 1
External IDsOMIM: 600036; MGI: 97450; HomoloGene: 7875; GeneCards: OTX1; OMA:OTX1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199770
NM_014562

NM_011023

RefSeq (protein)

NP_001186699
NP_055377

NP_035153

Location (UCSC)Chr 2: 63.05 – 63.06 MbChr 11: 21.94 – 21.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Close

Function

This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. The Otx gene is active in the region of the first gill arch, which is related to the upper and lower jaw and two of the bones of the ear.[7] A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.[6]

References

Further reading

Loading related searches...

Wikiwand - on

Seamless Wikipedia browsing. On steroids.