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Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia
Organic solute transporter beta, also known as OST-beta, is a protein which in humans is encoded by the OSTB gene.[5][6]
SLC51B | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | SLC51B, OSTB, OSTBETA, OSTbeta, solute carrier family 51 beta subunit, solute carrier family 51 subunit beta, PBAM2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 612085; MGI: 3582052; HomoloGene: 18721; GeneCards: SLC51B; OMA:SLC51B - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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OST-beta together with OST-alpha is able to transport estrone sulfate, taurocholate, digoxin, and prostaglandin E2 across cell membranes.[6][7] The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake.[7] The heterodimer furthermore is essential for intestinal bile acid transport.[8]
OST-alpha and OST-beta have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.[6]
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