OR3A3

Olfactory receptor 3A3 is a protein that in humans is encoded by the OR3A3 gene.^[5][6][7]

OR3A3
Identifiers
Aliases	OR3A3, OR17-137, OR17-16, OR17-201, OR3A6, OR3A7, OR3A8P, olfactory receptor family 3 subfamily A member 3
External IDs	MGI: 3030245; HomoloGene: 74999; GeneCards: OR3A3; OMA:OR3A3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 3,411,370 bp[1] End 3,424,070 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B5 Start 74,235,955 bp[2] End 74,243,476 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibialis anterior muscle testicle Ventricular system of neuraxis ventricular zone Mesencephalon lymph node substantia nigra placenta myometrium thigh Top expressed in colon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8392 258704 Ensembl ENSG00000159961 ENSMUSG00000054406 UniProt P47888 n/a RefSeq (mRNA) NM_012373 NM_001386098 NM_146709 RefSeq (protein) NP_036505 n/a Location (UCSC) Chr 17: 3.41 – 3.42 Mb Chr 11: 74.24 – 74.24 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[7]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000159961 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000054406 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H (Jul 1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum Mol Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID 8004088.
6. Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (Mar 1998). "Distribution of olfactory receptor genes in the human genome". Nat Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID 9500546. S2CID 31129045.
7. "Entrez Gene: OR3A3 olfactory receptor, family 3, subfamily A, member 3".

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gilad Y, Lancet D (2003). "Population differences in the human functional olfactory repertoire". Mol. Biol. Evol. 20 (3): 307–14. doi:10.1093/molbev/msg013. PMID 12644552.
• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, Rosenthal A, Clifton S, Roe B, Ferraz C, Demaille J, Lancet D (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. S2CID 23416814.

External links

• OR3A3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.