Nucleus reuniens

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Nucleus reuniens

The nucleus reuniens is a region of the thalamic midline nuclear group.[1][2] In the human brain, it is located in the interthalamic adhesion (massa intermedia).[3][4] It is also known as the medioventral nucleus.[5]

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The nucleus reuniens receives afferent input from a large number of structures, mainly from limbic and limbic-associated structures.[6] It sends projections to the medial prefrontal cortex, the hippocampus, perirhinal cortex, and entorhinal cortex,[7][8][9] although there exist sparse connections to many other afferent structures as well.[10]

The unique medial prefrontal cortex and hippocampal connectivity allows reuniens to regulate neural traffic in this cortical network related to changes in an organism's attentiveness,[11] making reuniens critical to associative learning,[12] memory retrieval,[13] memory generalization,[14] spatial route planning,[15] and resilience to stress.[16]

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